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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Paraoxonase 1 activity and lipid profile in schizophrenic patients
Asian Journal of Psychiatry, Volume 9, Year 2014
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Description
Objective: This study aimed to investigate the variations of paraoxonase 1 (PON1) activity and lipid profile in patients with schizophrenia and the association of this activity with the sociodemographic, clinical and therapeutical characteristics of this population. Patients and methods: Our cross-sectional study included 140 schizophrenic patients and 119 control subjects aged respectively 37.3. ±. 10.4 and 41.4. ±. 10 years. PON1 activity was determined using Konelab 30™ equipment (Thermo Electron Corporation). Plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (c-HDL) and low-density lipoprotein cholesterol (c-LDL) concentrations were determined using Cobas 6000™ (Roche Diagnostics), apolipoproteins (ApoA1, ApoB) and lipoprotein (a) (Lp(a)) were determined using Integra 400 plus (Roche Diagnostics). Results: Compared to controls, patients had no significant decrease of PON1 activity and significantly lower ApoA1, c-HDL levels, and significantly higher levels of TG, ApoB, Lp(a) and TC/c-HDL and ApoB/ApoA1 ratios. Furthermore, PON1 activity was correlated with TG/c-HDL ratio. The lowest PON1 activity was noted in obese patients, in paranoid sub-type and in patients treated with combination of typical and atypical antipsychotics without significant difference. Moreover, it was associated with gender and cigarette smoking but not with alcohol consumption status. Conclusion: Schizophrenic patients had a decrease in PON1 activity and perturbations in their lipid profiles that contribute to increase the risk of cardiovascular diseases. In addition, our results revealed that there was no association between the decrease of PON1 activity and any demographic or clinical characteristics. Therefore, such patients require specific care, particularly with regard to their lipid profile. © 2014 Elsevier B.V.
Authors & Co-Authors
Mabrouk, Hajer
Tunisia, Monastir
University Hospital of Monastir
Mechria, H.
Tunisia, Monastir
University Hospital of Monastir
Mechri, A.
Tunisia, Monastir
University Hospital of Monastir
Azizi, Islem
Tunisia, Monastir
University Hospital of Monastir
Neffati, Fadoua
Tunisia, Monastir
University Hospital of Monastir
Douki, Wahiba
Tunisia, Monastir
University Hospital of Monastir
Gaha, Lotfi
Tunisia, Monastir
University Hospital of Monastir
Najjar, M. F.
Tunisia, Monastir
University Hospital of Monastir
Statistics
Citations: 19
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1016/j.ajp.2013.12.019
ISSN:
18762018
e-ISSN:
18762026
Research Areas
Mental Health
Noncommunicable Diseases
Substance Abuse
Study Design
Cross Sectional Study
Study Approach
Quantitative