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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
BRCA1 and BRCA2 status in a central Sudanese series of breast cancer patients: Interactions with genetic, ethnic and reproductive factors
Breast Cancer Research and Treatment, Volume 102, No. 2, Year 2007
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Description
The etiology of breast cancer in Africa is scarcely investigated. Breast cancer was responsible for 456/2,233 cancer patients (20.4%) ascertained between 1999 and 2004 at Gezira University, Central Sudan. Male breast cancer accounted for 16/456 patients (3.5%), 275/440 female patients (62.5%) were premenopausal and 150/440 cases (34%) occurred in women with ≥5 childbirths. We characterized for germline BRCA1/2 mutations a one-year series of patients (34 females, 1 male) selected by diagnosis within age 40 years or male gender. Overall 33/35 patients were found to carry 60 BRCA1/2 variants, of which 17 (28%) were novel, 22 (37%) reported in populations from various geographic areas and 21 (35%) reported worldwide. Detected variants included 5 truncating mutations, one of which (in BRCA2) was in the male patient. The 55 non-truncating variants included 3 unclassified variants predicted to affect protein product and not co-occurring with a truncating mutation in the same gene. Patients were from different tribes but AMOVA showed that most BRCA1/2 variation was within individuals (86.41%) and patients clustered independently of tribe in a phylogenetic tree. Cluster analysis based on age at cancer diagnosis and reproductive variables split female patients in two clusters that, by factor analysis, were explained by low versus high scores of the total period occupied by pregnancies and lactation. The cluster with low scores comprised all 4 patients with truncating mutations and 3 of the 4 carriers of unclassified variants predicted to affect protein product. Our findings suggest that in Central Sudan BRCA1/2 represent an important etiological factor of breast cancer in males and young women less exposed to pregnancy and lactation. Factors other than BRCA1/2 may contribute to breast cancer in young highly multiparous women who breast-fed for prolonged periods. © 2007 Springer Science+Business Media B.V.
Authors & Co-Authors
Awadelkarim, Khalid Dafaallah
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Sudan, Wad Medani
University of Gezira
Aceto, Gitana Maria
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Veschi, Serena
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Elhaj, Ahmed Mohammed
Sudan, Wad Medani
University of Gezira
Morgano, Annalisa
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Mohamedani, Ahmed Abdalla
Sudan, Wad Medani
University of Gezira
Eltayeb, Elgaylani Abdalla
Sudan, Wad Medani
University of Gezira
Abuidris, Dafalla Omer
Sudan, Wad Medani
University of Gezira
Di Gioacchino, Mario
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Battista, Pasquale
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Verginelli, Fabio
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Cama, A.
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Elwali, Nasr Eldin
Sudan, Wad Medani
University of Gezira
Mariani-Costantini, Renato
Italy, Chieti
University of G. D'annunzio Chieti and Pescara
Statistics
Citations: 60
Authors: 14
Affiliations: 2
Identifiers
Doi:
10.1007/s10549-006-9303-z
ISSN:
01676806
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Locations
Sudan
Participants Gender
Male
Female