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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pilot study of terbinafine in children suffering from tinea capitis: evaluation of efficacy, safety and pharmacokinetics
British Journal of Dermatology, Volume 132, No. 1, Year 1995
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Description
In an open pilot study, 12 children with tinea capitis were treated for 6 weeks with oral terbinafine (125mg/day), and followed up 2 weeks later. The study was conducted to evaluate the efficacy, safety and pharmacokinetics of terbinafine. All patients were completely cured at the end of the treatment period, and there was no evidence of relapse at follow‐up. Seven had a negative culture after 3 weeks of treatment. The time to obtain culture conversion from positive to negative did not appear to be related to body weight, but to clinical severity at baseline. Terbinafine is well tolerated and safe over a 56‐day period. The kinetic data show a higher clearance of terbinafine in children compared with adults, with shorter α‐ and β‐phase elimination half‐lives. However, a longer terminal 7‐phase (at least 6 days) is observed, as in adults, after multiple dose administration, and this is related to elimination from the tissues. The plasma concentrations are comparable between children and adults at a steady state (125 mg/day). Copyright © 1995, Wiley Blackwell. All rights reserved
Authors & Co-Authors
NEJJAM, F.
Morocco
Hôpital Ibnou Rochd
ZAGULA, M.
France, Rueil-malmaison
Laboratoires Sundoz
Cabiac, M. D.
France, Rueil-malmaison
Laboratoires Sundoz
GUESSOUS, N.
Morocco
Hôpital Ibnou Rochd
Humbert, H.
France, Rueil-malmaison
Laboratoires Sundoz
Lakhdar, Hakima
Morocco
Hôpital Ibnou Rochd
Statistics
Citations: 81
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1111/j.1365-2133.1995.tb08632.x
ISSN:
00070963
e-ISSN:
13652133
Research Areas
Health System And Policy
Maternal And Child Health