Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Carbapenem resistance and Acinetobacter baumannii in senegal: The paradigm of a common phenomenon in natural reservoirs
PLoS ONE, Volume 7, No. 6, Article e39495, Year 2012
Notification
URL copied to clipboard!
Description
Incidence of carbapenem-resistant Acinetobacter baumannii is rising in several parts of the world. In Africa, data concerning this species and its resistance to carbapenems are limited. The objective of the present study was to identify the presence of A. baumannii carbapenem-resistant encoding genes in natural reservoirs in Senegal, where antibiotic pressure is believed to be low. From October 2010 to January 2011, 354 human head lice, 717 human fecal samples and 118 animal fecal samples were screened for the presence of A. baumannii by real time PCR targeting blaOXA51-like gene. For all samples positive for A. baumannii, the carbapenemase-hydrolysing oxacillinases blaOXA23-like and blaOXA24-like were searched for and sequenced, and the isolates harbouring an oxacillinase were genotyped using PCR amplification and sequencing of recA gene. The presence of A. baumannii was detected in 4.0% of the head lice, in 5.4% of the human stool samples and in 5.1% of the animal stool samples tested. No blaOXA24 gene was detected but six fecal samples and three lice were positive for blaOXA23-like gene. The blaOXA23-like gene isolated in lice was likely a new oxacillinase sequence. Finally, the A. baumannii detected in stools were all of recA genotype 3 and those detected in lice, of recA genotype 4. This study shows for the first time a reservoir of blaOXA23-like-positive gene in human head lice and stool samples in Senegal. © 2012 Kempf et al.
Authors & Co-Authors
Kempf, Marie Claude
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Rolain, Jean Marc
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Diatta, Georges
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Azza, Saïd
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Samb, Bissoum
Senegal, Dakar
Institut Pasteur de Dakar
Mediannikov, Oleg Y.
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Gassama-Sow, Amy
Senegal, Dakar
Institut Pasteur de Dakar
Diene, Seydina Mouhamadou
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Fénollar, Florence
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Raoult, Didier A.
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Statistics
Citations: 59
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0039495
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Study Design
Cohort Study
Study Locations
Senegal