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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Improving diagnostic capability for HPV disease internationally within the NIH-NIAID division of AIDS clinical trial networks
American Journal of Clinical Pathology, Volume 140, No. 6, Year 2013
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Description
Objectives: To evaluate an external quality assurance (EQA) program for the laboratory diagnosis of human papillomavirus (HPV) disease that was established to improve international research capability within the Division of AIDS at the National Institute of Allergy and Infectious Disease-supported Adult AIDS Clinical Trials Group network. Methods: A three-component EQA scheme was devised comprising assessments of diagnostic accuracy of cytotechnologists and pathologists using available EQA panels, review of quality and accuracy of clinical slides from local sites by an outside expert, and HPV DNA detection using a commercially available HPV test kit. Results: Seven laboratories and 17 pathologists in Africa, India, and South America participated. EQA scores were suboptimal for EQA proficiency testing panels in three of seven laboratories. There was good agreement between the local laboratory and the central reader 70% of the time (90% confidence interval, 42%-98%). Performance on the College of American Pathologists' HPV DNA testing panel was successful in all laboratories tested. Conclusions: The prequalifying EQA round identified correctable issues that will improve the laboratory diagnosis of HPV-related cervical disease at the participating international study sites and will provide a mechanism for ongoing education and continuous quality improvement. © American Society for Clinical Pathology.
Authors & Co-Authors
Godfrey, Catherine C.
Unknown Affiliation
Michelow, Pamela M.
Unknown Affiliation
Godard, Mandana
Unknown Affiliation
Sahasrabuddhe, Vikrant V.
Unknown Affiliation
Darden, Janice
Unknown Affiliation
Firnhaber, Cynthia S.
Unknown Affiliation
Wetherall, Neal T.
Unknown Affiliation
Bremer, James W.
Unknown Affiliation
Coombs, Robert W.
Unknown Affiliation
Wilkin, Timothy J.
Unknown Affiliation
Statistics
Citations: 10
Authors: 10
Affiliations: 12
Identifiers
Doi:
10.1309/AJCPIBIS19QIYHJY
ISSN:
00029173
e-ISSN:
19437722
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases