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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Nature Communications, Volume 10, No. 1, Article 1893, Year 2019
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Description
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (P Bonferroni < 1.06 x 10 −7 ). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10 −74 ) and BMI in pregnancy (3/914, p = 1.13x10 −3 ), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research. © 2019, The Author(s).
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Authors & Co-Authors
Küpers, Leanne Karen
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Netherlands, Groningen
Rijksuniversiteit Groningen
Netherlands, Wageningen
Wageningen University & Research
Monnereau, Claire
Netherlands, Rotterdam
Erasmus Mc
Sharp, Gemma C.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Yousefi, Paul Darius
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
United States, Berkeley
University of California, Berkeley
Ghantous, Akram Y.
France, Lyon
Centre International de Recherche Sur le Cancer
Page, Christian M.
Norway, Oslo
Folkehelseinstituttet
Norway, Oslo
Oslo Universitetssykehus
Wilcox, Allen James
United States, Bethesda
National Institutes of Health Nih
Czamara, Darina
Germany, Munich
Max Planck Institute of Psychiatry
Hoyo, Cathrine
United States, Raleigh
Nc State University
Just, Allan C.
United States, New York
Icahn School of Medicine at Mount Sinai
Bakulski, Kelly M.
United States, Ann Arbor
University of Michigan, Ann Arbor
Holloway, John W.
United Kingdom, Southampton
University of Southampton, Faculty of Medicine
United Kingdom, Southampton
University of Southampton
Everson, Todd M.
United States, Atlanta
Emory University
Xu, Cheng Jian
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Netherlands, Groningen
Rijksuniversiteit Groningen
Huang, Rae Chi
Australia, Perth
The University of Western Australia
Wielscher, Matthias
United Kingdom, London
Imperial College London
Ullemar, Vilhelmina
Sweden, Stockholm
Karolinska Institutet
Lahti, Jari M.T.
Finland, Helsinki
Helsingin Yliopisto
Van Dongen, Jenny
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Richardson, Tom G.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Magnus, Maria Christine
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Norway, Oslo
Folkehelseinstituttet
Nohr, Ellen Aagaard
Denmark, Odense
Syddansk Universitet
Duijts, Liesbeth
Netherlands, Wageningen
Wageningen University & Research
Netherlands, Rotterdam
Erasmus Mc
Zhang, Weiming
United States, Aurora
Colorado School of Public Health
DeMeo, Dawn Lisa
United States, Boston
Brigham and Women's Hospital
Jima, Dereje D.
United States, Raleigh
Nc State University
Bustamante, Mariona
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Centro de Regulacion Genomica, Barcelona
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Wright, Robert O.
United States, New York
Icahn School of Medicine at Mount Sinai
Karagas, Margaret Rita
United States, Hanover
Dartmouth College
Gehring, Ulrike
Netherlands, Utrecht
Universiteit Utrecht
Marsit, Carmen J.
United States, Atlanta
Emory University
Beilin, Lawerence Joseph
Australia, Perth
Uwa Medical School
Vonk, Judith M.
Netherlands, Groningen
Rijksuniversiteit Groningen
J̈arvelin, Märjo Riitta R.
United Kingdom, London
Imperial College London
Finland, Oulu
Oulun Yliopisto
Finland, Oulu
Oulu University Hospital
Örtqvist, Anne Kristina
Sweden, Stockholm
Karolinska Institutet
Villa, Pia M.
Finland, Helsinki
Helsingin Yliopisto
Moore, Sophie E.
United Kingdom, London
Medical Research Council
United Kingdom, London
King's College London
Willemsen, Gonneke A.H.M.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Håberg, Siri E.
Norway, Oslo
Folkehelseinstituttet
Sorensen, Thorkild I.A.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Denmark, Copenhagen
Københavns Universitet
Taylor, Jack A.
United States, Bethesda
National Institutes of Health Nih
Räikkönen, Katri
Finland, Helsinki
Helsingin Yliopisto
Kechris, Katerina J.
Netherlands, Rotterdam
Erasmus Mc
Nawrot, Tim Steve
Belgium, Hasselt
Universiteit Hasselt
Belgium, Leuven
Ku Leuven
Silver, Matt J.
United Kingdom, London
Medical Research Council
Gong, Yun Yun
United Kingdom, Leeds
University of Leeds
Kogevinas, Manolis
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Barcelona
Institut Municipal D'investigacio Medica
Litonjua, Augusto A.
United States, Boston
Brigham and Women's Hospital
Eskenazi, Brenda
United States, Berkeley
University of California, Berkeley
Mbarek, Hamdi
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Maguire, Rachel Loflin
United States, Raleigh
Nc State University
United States, Durham
Duke University Medical Center
Dwyer, Terence
United Kingdom, Oxford
The George Institute, uk
Vrijheid, M.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Baccarelli, Andrea A.
United States, New York
Mailman School of Public Health
United States, New York
Columbia University
Croen, Lisa A.
United States, Oakland
Kaiser Permanente
Anderson, Denise R.
Australia, Perth
The University of Western Australia
Sébert, Sylvain P.
Finland, Oulu
Oulun Yliopisto
United Kingdom, London
Imperial College London
Kere, Juha F.
Finland, Helsinki
Folkhälsan Institute of Genetics
Sweden, Stockholm
Karolinska Institutet
United Kingdom, London
King's College London
Karlsson, Robert
Sweden, Stockholm
Karolinska Institutet
Arshad, Syed Hasan
United Kingdom, Southampton
University of Southampton, Faculty of Medicine
Håmålåinen, Esa K.
Finland, Helsinki
Helsinki University Hospital
Routledge, Michael N.
United Kingdom, Leeds
University of Leeds
Boomsma, Dorret I.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Feinberg, Andrew P.
United States, Baltimore
Johns Hopkins School of Medicine
Moisse, Matthieu
Belgium, Leuven
Ku Leuven
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Fallin, M. D. Daniele
United States, Baltimore
Johns Hopkins University
Melén, Erik
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Sachsska Barn- Och Ungdomssjukhuset
Prentice, Andrew M.
United Kingdom, London
Medical Research Council
Kajantie, Eero O.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
Finland, Oulu
Oulun Yliopisto
Almqvist, Catarina
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Karolinska Universitetssjukhuset
Oken, Emily
United States, Boston
Harvard Pilgrim Health Care Institute
Dabelea, Dana M.
United States, Aurora
University of Colorado Anschutz Medical Campus
Boezen, H. M.
Netherlands, Groningen
Rijksuniversiteit Groningen
Melton, Phillip Edward
Australia, Perth
Centre for Genetic Origins of Health and Disease
Australia, Perth
The Faculty of Health Sciences
Wright, Rosalind John
United States, New York
Icahn School of Medicine at Mount Sinai
Koppelman, Gerard H.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Trevisi, Letizia
United States, Boston
Harvard Medical School
Hivert, Marie France
Canada, Sherbrooke
Université de Sherbrooke
United States, Boston
Harvard Pilgrim Health Care Institute
United States, Boston
Massachusetts General Hospital
Sunyer, Jordi A.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Barcelona
Institut Municipal D'investigacio Medica
Murphy, Susan K.
United States, Durham
Duke University Medical Center
Corpeleijn, E.
Netherlands, Groningen
Rijksuniversiteit Groningen
Wiemels, Joseph L.
United States, San Francisco
University of California, San Francisco
Holland, Nina Titenko
United States, Berkeley
University of California, Berkeley
Herceg, Zdenko
France, Lyon
Centre International de Recherche Sur le Cancer
Binder, Elisabeth B.
Germany, Munich
Max Planck Institute of Psychiatry
United States, Atlanta
Emory University School of Medicine
Smith, George D.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Jaddoe, Vincent W.V.
Netherlands, Rotterdam
Erasmus Mc
Lie, Rolv Terje
Norway, Oslo
Folkehelseinstituttet
Norway, Bergen
Universitetet I Bergen
Nystad, Wenche
Norway, Oslo
Folkehelseinstituttet
London, Stephanie J.
United States, Bethesda
National Institutes of Health Nih
Lawlor, Debbie A.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Relton, Caroline L.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Snieder, Harold
Netherlands, Groningen
Rijksuniversiteit Groningen
Felix, Janine Frédérique
Netherlands, Rotterdam
Erasmus Mc
Statistics
Citations: 113
Authors: 94
Affiliations: 76
Identifiers
Doi:
10.1038/s41467-019-09671-3
ISSN:
20411723
Research Areas
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Systematic review