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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Risk genotypes and haplotypes of the GLUT1 gene for type 2 diabetic nephropathy in the Tunisian population
Annals of Human Biology, Volume 35, No. 5, Year 2008
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Description
Objective: Diabetic nephropathy (DN) is a long-term complication of both type 1 and type 2 diabetes. Genetic studies on DN have been of little help so far, since several genetic association studies have shown conflicting results. Here we report the findings of a case-control study on five SNPs in the glucose transporter 1 (GLUT1) gene. The study investigated the association of five GLUT1 genotypes and haplotypes with DN. Research design and methods: All subjects, 126 DN (cases) and 273 type 2 diabetes (controls), were genotyped using the polymerase chain reaction restriction fragment length polymorphism. Results: The TT and the AA genotypes of the Haell and Enh2 SNP1, increased the risk of DN. The study also identified CGT as the highest risk haplotype (4.4-fold) followed by CAT with an increased risk of DN of 2.6-fold. Conclusions: The GLUT1 gene confers susceptibility to DN in type 2 diabetes patients in the Tunisian population. © 2008 Informa UK Ltd.
Authors & Co-Authors
Makni, Kaouthar
Tunisia, Sfax
Centre de Biotechnologie de Sfax
France
Cnrs 135
Jarraya, FaïÇal
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Tunisia, Sfax
Chu Hedi-chaker
France
Cnrs 135
Rebaï, Maha
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Mnif, Fatma
Tunisia, Sfax
Chu Hedi-chaker
Boudawara, Mouhamed
Tunisia, Sfa
Social National Case of Sfax
Hamza, Naziha
Tunisia, Sfa
Social National Case of Sfax
Rekik, Nabila Mejdoub
Tunisia, Sfax
Chu Hedi-chaker
Abid, Mouhamed
Tunisia, Sfax
Chu Hedi-chaker
Hachicha, Jamil
Tunisia, Sfax
Chu Hedi-chaker
Granier, Claude
France, Paris
Cnrs Centre National de la Recherche Scientifique
France
Cnrs 135
REBAI, AHMED
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Ayadi, Hammadi
Tunisia, Sfax
Centre de Biotechnologie de Sfax
France
Cnrs 135
Statistics
Citations: 17
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1080/03014460802247142
e-ISSN:
14645033
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study