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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Vitamin A supplements and mortality related to measles: A randomised clinical trial
British Medical Journal (Clinical research ed.), Volume 294, No. 6567, Year 1987
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Description
One hundred and eighty children admitted with measles were randomly allocated to receive routine treatment alone or with additional large doses of vitamin A (200 000 IU orally immediately and again the next day). Baseline characteristics of the two groups were virtually identical for, age, severity of measles, and vitamin A and general nutritional states. In 91% of the children serum vitamin A concentrations were less than 0·56 μmol/1. Of the 88 subjects given vitamin A supplements, six (7%) died; of the 92 controls, 12 (13%) died (p=0·13). This difference in mortality was most obvious for children aged under 2 years (one death out of 46 children receiving supplements versus seven deaths out of 42 controls; p<0·05) and for cases complicated by croup or laryngotracheobronchitis. Mortality was several times higher in marasmic than in better nourished children, regardless of study allocation (p<0·01). © 1987, British Medical Journal Publishing Group. All rights reserved.
Authors & Co-Authors
Barclay, Andrew J.G.
Tanzania, Dodoma
Mvumi Hospital
Foster, Allen
Tanzania, Dodoma
Mvumi Hospital
Sommer, Alfred
United States, Baltimore
Wilmer Eye Institute
Statistics
Citations: 272
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1136/bmj.294.6567.294
ISSN:
02670623
Research Areas
Infectious Diseases
Maternal And Child Health