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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evaluation of oxidative stress and antioxidant status of pregnant women suffering from malaria in Cameroon
Indian Journal of Clinical Biochemistry, Volume 24, No. 3, Year 2009
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Description
Oxidative stress is thought to be involved in the pathophysiology of malaria, especially in pregnancy where natural resistance is markedly reduced. In the present study we investigated oxidative stress in 315 pregnant women out of which 159 had Plasmodium falciparum malaria and 154 controls. We evaluated the level of lipid peroxidation products (MDA level) in the plasma, the activity of erythrocyte antioxidant defense enzymes, superoxide dismutase (SOD, EC: 1.15.1.1) and catalase (Cat, EC: 1.11.1.6) as well as the ability to resist oxidative stress by the FRAP (Ferric Reducing Ability of Plasma) assay. Total erythrocyte protein levels were also examined. For the two groups of patients, several differences between the biochemical parameters tested were found. Median parasitaemia in women with malaria was 25,392 parasites/μl of blood (Range1200-82000), while in controls we had no parasites found in thin and thick smears. Levels of lipid peroxidation products (MDA) were significantly higher in patients with parasitemia than in healthy asymptomatic volunteers (mean: 0.844 ± 0.290 and 0.384 ± 0.129 respectively, p<0.001). This MDA level was higher in primigravidea and also correlates well with parasite density (p<0.001). Catalase activity in erythrocytes of women with malaria did not differ statistically from that of controls. In contrast, SOD activity of patients with malaria was found to be significantly higher than that of controls (mean: 0.7899 ± 0.2777 and 0.4263 ± 0.2629 respectively, p<0.05). FRAP values declined, from parasitemic patients (1.4619 ± 0.6565) compare to controls (2.4396 ± 0.8883, p<0.05), particularly in the first and third trimester of gestation (p<0.05 and p<0.01 respectively). Finally, total erythrocyte protein concentrations of women with malaria did not differ from that of the controls. Our results suggest an imbalance between oxidants and antioxidants in pregnant women suffering from malaria, a situation which could lead to severe damage for either the mother or the fetus. Therefore, further research should be done to assess the potential benefits of antioxidant supplementation for the pregnant women suffering from malaria. © 2009 Association of Clinical Biochemists of India.
Authors & Co-Authors
Tiyong Ifoue, Serge Herve
Cameroon, Yaounde
Université de Yaoundé I
Teugwa Mofor, C.
Cameroon, Yaounde
Université de Yaoundé I
Gouado, Inocent
Cameroon, Douala
University of Douala
Této, Georges
Cameroon, Yaounde
Université de Yaoundé I
Asonganyi, Tazoacha
Cameroon, Yaounde
Université de Yaoundé I
Amvam-Zollo, Paul Henri
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 24
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1007/s12291-009-0054-6
ISSN:
09701915
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Locations
Cameroon
Participants Gender
Female