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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Eosinophils as mediators of antibody-dependent damage to schistosomula
Nature, Volume 256, No. 5520, Year 1975
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Description
WE have reported previously1 that damage to schistosomula can be assayed by measuring release of 51Cr from labelled larvae. Using this technique, we have shown that schistosomula can be damaged by a combination of normal human peripheral blood leukocytes and of heat-inactivated sera from patients infected with Schistosoma mansoni1. We now present evidence that the eosinophil is substantially the most active mediator of damage in normal peripheral blood, but that cells from eosinophilic patients are relatively inactive. © 1975 Nature Publishing Group.
Authors & Co-Authors
Butterworth, Anthony E.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Sturrock, Robert F.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Houba, Vaclav
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Mahmoud, Adel A.F.
United States, Cleveland
Case Western Reserve University
Sher, Alan F.
United States, Boston
Brigham and Women's Hospital
Rees, Philip H.
Kenya, Nairobi
University of Nairobi
Statistics
Citations: 350
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1038/256727a0
ISSN:
00280836