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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Design, synthesis and biological evaluation of some novel substituted quinazolines as antitumor agents
European Journal of Medicinal Chemistry, Volume 79, Year 2014
Notification
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Description
A novel series of 6-chloro-2-p-tolylquinazolinone and substituted-(4- methylbenzamido)benzamide (1-20) were designed, synthesized and evaluated for their in-vitro antitumor activity. Compounds 3, 14 and 16 possessed remarkable broad-spectrum antitumor activity. Compound 16 was found to be a particularly active growth inhibitor of the renal cancer (GI50 = 4.07 μM), CNS cancer (GI50 = 7.41 μM), ovarian cancer (GI50 = 7.41 μM) and non-small cell lung cancer (GI50 = 7.94 μM). Compound 16 ranks as nearly 1.5-fold more potent (mean GI50 = 15.8 μM) compared to 5-FU (mean GI50 = 22.6 μM). © 2014 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Alanazi, Amer M.
Saudi Arabia, Riyadh
College of Pharmacy
Abdel-Aziz, Alaa A.M.
Saudi Arabia, Riyadh
College of Pharmacy
Egypt, Mansoura
Faculty of Pharmacy
Al-Suwaidan, Ibrahim A.
Saudi Arabia, Riyadh
College of Pharmacy
Abdel-Hamide, Sami G.
Saudi Arabia, Al Kharj
Prince Sattam Bin Abdulaziz University
Shawer, Taghreed Z.
Egypt, Cairo
Faculty of Pharmacy
El-Azab, Adel S.
Saudi Arabia, Riyadh
College of Pharmacy
Egypt, Cairo
Faculty of Pharmacy
Statistics
Citations: 63
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejmech.2014.04.029
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Cancer