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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Immunohistopathological and biochemical changes in Schistosoma mansoni-infected mice treated with artemether
Journal of Infection, Volume 55, No. 5, Year 2007
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Description
Objective: To investigate immune mechanisms possibly involved in the amelioration of histopathological changes in livers of Schistosoma mansoni-infected mice treated with artemether (ART), including liver functions and apoptotic changes. Methods: Male CD-1 Swiss albino mice were infected with Schistosoma mansoni and treated with praziquantel (PZQ) 6 weeks post-infection (PI) (500 mg/kg/day x2) and/or ART in double dose (each of 400 mg/kg) 4 and 6 weeks PI. Parasitological parameters, liver functions and histopathological changes including T-lymphocyte profile and apoptotic changes were assessed. Results: Eight weeks PI, although the reduction in worm burden in mice treated with ART plus PZQ was comparable to that in PZQ-treated mice, yet there was complete absence of eggs and typical granulomas. The ratio of T-helper/cytotoxic cells was in favor of T-helper in infected control and in mice treated with both drugs. This ratio was 0.9:1 and 0.7:1 in PZQ and ART-treated groups, respectively, with moderate apoptotic changes in the latter. All biochemical parameters expressing liver function were improved with all treatment regimens. Conclusions: Administration of ART in addition to PZQ resulted in absence of eggs and typical granulomas with less apoptotic changes than in ART-treated mice. Improved liver functions with higher apoptosis in ART-treated mice may suggest enhanced necrotic cell death/regenerative changes. © 2007 The British Infection Society.
Authors & Co-Authors
Botros, Sanaa
Egypt, Giza
Immunology and Therapeutic Evaluation Division
Mahmoud, Madiha R.
Egypt, Giza
Immunology and Therapeutic Evaluation Division
Moussa, Mona Mohammed
Egypt, Giza
Clinical Lab Research Division
Nosseir, Mona M.F.
Egypt, Giza
Clinical Lab Research Division
Statistics
Citations: 40
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.jinf.2007.07.022
ISSN:
01634453
Research Areas
Cancer
Participants Gender
Male