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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
In vivo lipid diffusion coefficient measurements in rat bone marrow
Magnetic Resonance Imaging, Volume 27, No. 6, Year 2009
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Description
The diffusion coefficient of lipids, Dl, within bone marrow, fat deposits and metabolically active intracellular lipids in vivo will depend on several factors including the precise chemical composition of the lipid distribution (chain lengths, degree of unsaturation, etc.) as well as the temperature. As such, Dl may ultimately prove of value in assessing abnormal fatty acid distributions linked to diseases such as cystic fibrosis, diabetes and coronary heart disease. A sensitive temperature dependence of Dl may also prove of value for MR-guided thermal therapies for bone tumors or disease within other fatty tissues like the breast. Measuring diffusion coefficients of high molecular weight lipids in vivo is, however, technically difficult for a number of reasons. For instance, due to the much lower diffusion coefficients compared to water, much higher b factors than those used for central nervous system applications are needed. In addition, the pulse sequence design must incorporate, as much as possible, immunity to motion, susceptibility and chemical shift effects present whenever body imaging is performed. In this work, high b-factor line scan diffusion imaging sequences were designed, implemented and tested for Dl measurement using a 4.7-T horizontal bore animal scanner. The gradient set available allowed for b factors as high as 0.03 μs/nm2 (30,000 s/mm2) at echo times as short as 42 ms. The methods were used to measure lipid diffusion coefficients within the marrow of rat paws in vivo, yielding lipid diffusion coefficients approximately two orders of magnitude smaller than typical tissue water diffusion coefficients. Phantom experiments that demonstrate the sensitivity of lipid diffusion coefficients to chain length and temperature were also performed. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Ababneh, Zaid Q.
Jordan, Irbid
Yarmouk University
Belœil, Hélène
United States, Boston
Boston Children's Hospital
Berde, Charles B.
United States, Boston
Boston Children's Hospital
Ababneh, Anas M.
Jordan, Irbid
Yarmouk University
Maier, Stephan E.
United States, Boston
Boston Children's Hospital
Mulkern, Robert V.
United States, Boston
Boston Children's Hospital
United States, Boston
Brigham and Women's Hospital
Statistics
Citations: 25
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.mri.2008.11.004
ISSN:
0730725X
Research Areas
Environmental
Noncommunicable Diseases