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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Fungal infection in patients with end-stage liver disease: Low frequency or low index of suspicion
International Journal of Infectious Diseases, Volume 23, Year 2014
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Description
Background: End-stage liver disease (ESLD) is associated with dysregulation of the immune system and increased susceptibility to infections. Although invasive fungal infection (IFI) is a growing public health problem, studies of IFI in ESLD are lacking. The aims of this study were to screen for IFI in ESLD and to assess risk factors and serum interleukin 17 (IL-17) as a marker of the cellular immune response. Methods: Both blood and ascitic fluid samples were collected from 46 patients with ESLD for fungal culture and PCR. Serum IL-17 levels were determined. Results: Seven patients had isolated IFI (four had spontaneous fungal peritonitis, two had fungemia, and one had a disseminated fungal infection) and five cases had combined fungal and bacterial infections. Spontaneous fungal peritonitis was attributed to Candida species, while fungemia was caused by Aspergillus species. Patients with IFI had higher serum IL-17 levels and increased mortality compared to patients without IFI. A history of antibiotic use (p = 0.002), higher model for end-stage liver disease (MELD) scores (p = 0.04), and hepatorenal syndrome (p = 0.006) were risk factors for IFI. Conclusions: Patients with ESLD had a low frequency of IFI; however, in patients with these infections, delayed diagnosis and treatment may contribute to a high fatality rate. Thus, clinicians should have a high index of suspicion for this unusual but lethal entity, as prompt detection and appropriate treatment can improve the outcome. © 2014 The Authors.
Authors & Co-Authors
Hassan, Elham Ahmed
Egypt, Asyut
Faculty of Medicine
El-Rehim, Abeer S.Abd
Egypt, Asyut
Faculty of Medicine
Hassany, Sahar Mohamed
Egypt, Asyut
Faculty of Medicine
Ahmed, Asmaa Omar
Egypt, Asyut
Faculty of Medicine
Elsherbiny, Nahla M.
Egypt, Asyut
Faculty of Medicine
Abdel-Rahim, Mona Hussein
Egypt, Asyut
Faculty of Medicine
Statistics
Citations: 75
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1016/j.ijid.2013.12.014
ISSN:
12019712
e-ISSN:
18783511