Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Polymerase chain reaction to detect hepatitis b virus dna and rna sequences in primary liver cancers from patients negative for hepatitis b surface antigen
New England Journal of Medicine, Volume 323, No. 2, Year 1990
Notification
URL copied to clipboard!
Description
Background and Methods. The role of hepatitis B virus (HBV) in the course of patients with primary liver cancer who are negative for hepatitis B surface antigen has been debated. We used the polymerase chain reaction to evaluate 28 such patients for the presence of DNA and RNA sequences of the virus; 22 of these patients had associated cirrhosis. The patients were from areas with different prevalences of HBV infection (South Africa, Italy, France, and Japan). Results. Antibodies to the surface and core antigens of HBV were detected in 10 of the 23 patients tested. HBV DNA sequences were detected in 17 of the 28 patients, including 8 of the 10 with HBV antibodies and 6 of 13 without HBV serologic markers. HBV RNA molecules were found in four of five tumors tested. Conclusions. Our investigation indicates that transcriptionally active HBV genomes are present in various geographic areas among patients with liver cancer who are negative for hepatitis B surface antigen. This observation is consistent with an etiologic role for the virus in the development of these tumors. (N Engl J Med 1990; 323:80–5.). © 1990, Massachusetts Medical Society. All rights reserved.
Authors & Co-Authors
Paterlini, Patrizia
France, Paris
Inserm
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Gerken, G.
France, Paris
Inserm
Nakajima, E.
France, Paris
Institut Pasteur, Paris
Terre, S.
France, Paris
Inserm
Derrico, A.
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Grigioni, W.
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Nalpas, Bertrand
France, Paris
Hopital Laennec
Franco, Dominique
Unknown Affiliation
Wands, Jack R.
South Africa, Johannesburg
University of Johannesburg
Kew, Michael Charles
South Africa, Johannesburg
University of Johannesburg
Pisi, E.
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Tiollais, Pierre
France, Paris
Institut Pasteur, Paris
Bréchot, Christian B.
France, Paris
Inserm
France, Paris
Institut Pasteur, Paris
France, Paris
Hopital Laennec
Statistics
Citations: 266
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1056/NEJM199007123230202
ISSN:
00284793
e-ISSN:
15334406
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Locations
South Africa