Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effectiveness of maternal influenza immunization in mothers and infants
New England Journal of Medicine, Volume 359, No. 15, Year 2008
Notification
URL copied to clipboard!
Description
Background: Young infants and pregnant women are at increased risk for serious consequences of influenza infection. Inactivated influenza vaccine is recommended for pregnant women but is not licensed for infants younger than 6 months of age. We assessed the clinical effectiveness of inactivated influenza vaccine administered during pregnancy in Bangladesh. Methods: In this randomized study, we assigned 340 mothers to receive either inactivated influenza vaccine (influenza-vaccine group) or the 23-valent pneumococcal polysaccharide vaccine (control group). Mothers were interviewed weekly to assess illnesses until 24 weeks after birth. Subjects with febrile respiratory illness were assessed clinically, and ill infants were tested for influenza antigens. We estimated the incidence of illness, incidence rate ratios, and vaccine effectiveness. Results: Mothers and infants were observed from August 2004 through December 2005. Among infants of mothers who received influenza vaccine, there were fewer cases of laboratory-confirmed influenza than among infants in the control group (6 cases and 16 cases, respectively), with a vaccine effectiveness of 63% (95% confidence interval [CI], 5 to 85). Respiratory illness with fever occurred in 110 infants in the influenza-vaccine group and 153 infants in the control group, with a vaccine effectiveness of 29% (95% CI, 7 to 46). Among the mothers, there was a reduction in the rate of respiratory illness with fever of 36% (95% CI, 4 to 57). Conclusions: Inactivated influenza vaccine reduced proven influenza illness by 63% in infants up to 6 months of age and averted approximately a third of all febrile respiratory illnesses in mothers and young infants. Maternal influenza immunization is a strategy with substantial benefits for both mothers and infants. (ClinicalTrials.gov number, NCT00142389.) Copyright © 2008 Massachusetts Medical Society.
Authors & Co-Authors
Zaman, Khalequzzaman S.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Roy, Eliza
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Arifeen, Shams El I.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Raqib, Rubhana
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Wilson, Emily B.
United States, Baltimore
Johns Hopkins University
Omer, Saad B.
United States, Baltimore
Johns Hopkins University
Breiman, Robert F.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Steinhoff, Mark C.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
United States, Baltimore
Johns Hopkins University
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Statistics
Citations: 1,035
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1056/NEJMoa0708630
ISSN:
00284793
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Female