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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Coinfection with Schistosoma mansoni is associated with decreased HIV-specific cytolysis and increased IL-10 production
Journal of Immunology, Volume 174, No. 8, Year 2005
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Description
Impaired virus-specific immune responses have previously been observed with Schistosoma mansoni coinfection. We characterized Gag-specific responses in HIV-1-positive Ugandans with and without S. mansoni coinfection. We observed no significant difference in the frequency of IFN-γ CD8+ T cells between the two groups. Interestingly, expression of CD107, a marker for cytolytic activity, was significantly lower in volunteers with S. mansoni coinfection compared with those with HIV-1 infection alone (p = 0.002). In contrast, the frequency of IL-10-positive Gag-specific CD8+ T cell responses was higher in volunteers with S. mansoni coinfection (p = 0.004). Analysis of human CMV-specific CD8+ T cell responses in the same individuals failed to reveal a similar pattern of altered CD107 and IL-10 expression. Our results suggest that S. mansoni coinfection is associated with decreased Gag-specific CD8+ cytolytic T cell responses and increased number of Gag-specific IL-10 positive CD8+ T cells. Our findings may have important implications toward the implementation of HIV preventive and therapeutic programs in Africa. Copyright © 2005 by The American Association of Immunologists, Inc.
Authors & Co-Authors
McElroy, Michael D.
United States, Sacramento
California Department of Health Services
Elrefaei, Mohamed
United States, Sacramento
California Department of Health Services
Jones, Norman G.
United States, Sacramento
California Department of Health Services
Ssali, Francis N.
Uganda, Kampala
Joint Clinical Research Center Uganda
Mugyenyi, Peter N.
Uganda, Kampala
Joint Clinical Research Center Uganda
Barugahare, Banson John
Uganda, Kampala
Joint Clinical Research Center Uganda
Cao, Huyen L.
United States, Sacramento
California Department of Health Services
United States, Washington, D.c.
United States Department of Health and Human Services
Statistics
Citations: 51
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.4049/jimmunol.174.8.5119
ISSN:
00221767
Research Areas
Infectious Diseases