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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Low prevalence of detectable HIV plasma viremia in patients treated with antiretroviral therapy in Burkina Faso and Mali
Journal of Acquired Immune Deficiency Syndromes, Volume 48, No. 4, Year 2008
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Description
BACKGROUND:: Sub-Saharan Africa has seen dramatic increases in the numbers of people treated with antiretroviral therapy (ART). Although standard ART regimens are now universally applied, viral load measurement is not currently part of standard monitoring protocols in sub-Saharan Africa. METHODS:: We describe the prevalence of inadequate virological response (IVR) to ART (viral load ≥ 500 copies/mL) and identify factors associated with this outcome in 606 HIV-positive patients treated for at least 6 months. Recruitment took place in 7 hospitals and community-based sites in Bamako and Ouagadougou, and information was collected using medical charts and interviews. RESULTS:: The overall prevalence of IVR in treatment-naive patients was 12.3% and 24.4% for pretreated patients. There were no differences in rates of IVR according to ART delivery sites and time on treatment. Patients living farther away [odds ratio (OR) = 2.48; 95% confidence interval (CI) 1.40 to 4.39], those on protease inhibitor or nucleoside reverse transcriptase inhibitor regimens (OR = 3.23; 95% CI 1.79 to 5.82) and those reporting treatment interruptions (OR = 2.36; 95% CI 1.35 to 4.15), had increased odds of IVR. Immune suppression (OR = 3.32, 95% CI 1.94 to 5.70) and poor self-rated health (OR = 2.00; 95% CI 1.17 to 3.41) were also associated with IVR. CONCLUSIONS:: Sufficient expertise and dedication exist in public hospital and community-based programs to achieve rates of treatment success comparable to better-resourced settings. © 2008 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Boileau, Catherine R.
Canada, Montreal
Université Mcgill
Nguyen, Vinh Kim
Canada, Montreal
University of Montreal
Sylla, Mohamed
Canada, Montreal
University of Montreal
MacHouf, Nimâ
Canada, Montreal
Clinique Médicale L'actuel
Chamberland, Annie
Canada, Montreal
University of Montreal
Traoré, Hammar Alassane
Mali, Bamako
Hopital National du Point g
Niamba, Pascal Antoine
Burkina Faso, Ouagadougou
Universitaire Yalgado-ouédraogo
Diallo, Ismaël P.
Burkina Faso, Ouagadougou
Universitaire Yalgado-ouédraogo
Maïga, Moussa Youssouffa
Mali, Bamako
Hopital Gabriel Toure
Cissé, Mamadou C.
Mali, Bamako
Centre de Soins
Rashed, Sélim
Canada, Montreal
University of Montreal
Tremblay, Cécile L.
Canada, Montreal
University of Montreal
Statistics
Citations: 30
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1097/QAI.0b013e31817dc416
ISSN:
15254135
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Burkina Faso
Mali