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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Efficacy of Olyset® Plus, a New Long-Lasting Insecticidal Net Incorporating Permethrin and Piperonil-Butoxide against Multi-Resistant Malaria Vectors
PLoS ONE, Volume 8, No. 10, Article e75134, Year 2013
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Description
Due to the rapid extension of pyrethroid resistance in malaria vectors worldwide, manufacturers are developing new vector control tools including insecticide mixtures containing at least two active ingredients with different mode of action as part of insecticide resistance management. Olyset® Plus is a new long-lasting insecticidal net (LLIN) incorporating permethrin and a synergist, piperonyl butoxide (PBO), into its fibres in order to counteract metabolic-based pyrethroid resistance of mosquitoes. In this study, we evaluated the efficacy of Olyset® Plus both in laboratory and field against susceptible and multi-resistant malaria vectors and compared with Olyset Net, which is a permethrin incorporated into polyethylene net. In laboratory, Olyset® Plus performed better than Olyset® Net against susceptible Anopheles gambiae strain with a 2-day regeneration time owing to an improved permethrin bleeding rate with the new incorporation technology. It also performed better than Olyset® Net against multiple resistant populations of An. gambiae in experimental hut trials in West Africa. Moreover, the present study showed evidence for a benefit of incorporating a synergist, PBO, with a pyrethroid insecticide into mosquito netting. These results need to be further validated in a large-scale field trial to assess the durability and acceptability of this new tool for malaria vector control. © 2013 Pennetier et al.
Authors & Co-Authors
Pennetier, Cédric
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Bouraïma, Aziz
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Chandre, Fabrice
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Piameu, Michael
Cameroon, Yaounde
Laboratory of Medical Entomology
Cameroon, Yaounde
Catholic University of Central Africa
Etang, Josiane
Cameroon, Yaounde
Laboratory of Medical Entomology
Cameroon, Douala
University of Douala
Rossignol, Marie
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Sidick, Ibrahim
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Zogo, Barnabas Mahugnon
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Lacroix, Marie Noëlle
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Yadav, Rajpal Singh
Switzerland, Geneva
Organisation Mondiale de la Santé
Pigeon, Olivier
Belgium, Gembloux
Wallon Agricultural Research Centre
Corbell, Vincent
Thailand, Bangkok
Kasetsart University
Statistics
Citations: 105
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1371/journal.pone.0075134
e-ISSN:
19326203
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Locations
Multi-countries