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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pilot evaluation of short-term changes in macular pigment and retinal sensitivity in different phenotypes of early age-related macular degeneration after carotenoid supplementation
British Journal of Ophthalmology, Volume 101, No. 6, Year 2017
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Description
Purpose To investigate the response of carotenoid supplementation in different phenotypes of early age-related macular degeneration (AMD) by measuring macular pigment optical density (MPOD) and retinal sensitivity. Methods Consecutive patients with only medium/large drusen and only reticular pseudodrusen (RPD) and age-matched and sex-matched controls were enrolled. At baseline, participants underwent a complete ophthalmological examination including measurement of best-corrected visual acuity (BCVA), MPOD and retinal sensitivity. Patients were put on vitamin supplementation (lutein 10 mg/day, zeaxanthin 2 mg/day) and 3 months later underwent a repeated ophthalmological examination. Results Twenty patients with medium/large drusen, 19 with RPD and 15 control subjects were included. At baseline, in controls, mean MPOD and BCVA were significantly higher compared with RPD (p=0.001 and p=0.01) but similar to medium/large drusen (p=0.9 and p=0.4). Mean retinal sensitivity was significantly higher in controls compared with RPD and medium/large drusen (for all p<0.0001). After 3 months of carotenoid supplementation the mean MPOD significantly increased in RPD (p=0.002), thus showing no more difference compared with controls (p=0.3); no significant changes were found in mean retinal sensitivity and BCVA (p=0.3 and p=0.7). Medium/large drusen did not show significant changes on MPOD, retinal sensitivity and BCVA (p=0.5, p=0.7 and p=0.7, respectively). Conclusions Patients with early AMD, especially RPD phenotype, show lower macular sensitivity and MPOD than controls. After supplementation, MPOD significantly increased in RPD. These results suggest different pathophysiology for RPD as compared with medium/large drusen and may open new ways to identifying further therapeutic targets in this phenotype of early AMD. © 2016 Published by the BMJ Publishing Group Limited.
Authors & Co-Authors
Corvi, Federico
France, Creteil
Centre Hospitalier Intercommunal Creteil
Italy, Milan
Irccs Ospedale San Raffaele
Souied, Éric H.
France, Creteil
Centre Hospitalier Intercommunal Creteil
Falfoul, Yousra
France, Creteil
Centre Hospitalier Intercommunal Creteil
Jung, Camille
France, Creteil
Centre Hospitalier Intercommunal Creteil
Querques, Giuseppe
France, Creteil
Centre Hospitalier Intercommunal Creteil
Italy, Milan
Irccs Ospedale San Raffaele
Statistics
Citations: 17
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1136/bjophthalmol-2016-309115
ISSN:
00071161
Research Areas
Health System And Policy