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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Leukemia during pregnancy: Long term follow up of 32 cases from a single institution
Hematology/ Oncology and Stem Cell Therapy, Volume 7, No. 2, Year 2014
Notification
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Description
Background and objectives There is limited information regarding the outcome of patients treated for leukemia during pregnancy. This study was performed on all cases of leukemia during pregnancy identified in our institution leukemia database. Patients and methods It is a retrospective study from our existing database. Thirty two cases were identified among the cohort of patients treated for acute and chronic leukemia between January 1991 and July 2003. Results Among the acute leukemia patients (n = 21), 10 patients (47.6%) received chemotherapy during pregnancy, seven had live birth and three had spontaneous abortion. No teratogenicity or congenital malformations or postnatal complication were reported. The remaining 11 (52.4%) were not given chemotherapy while pregnant; three patients presented after 34 weeks of gestation ending in normal live births and then received chemotherapy and eight patients had abortion before starting chemotherapy. Among the chronic myeloid leukemia (CML) patients (n = 11), nine patients received hydroxyurea, one patient received alfa-interferon and one patient was treated with leukapheresis. Eight patients had normal live births and three patients had abortion. Out of the 32 patients, 18 patients (56.2%) subsequently underwent HLA matched sibling allogeneic stem cell transplantation, seven for acute myeloid leukemia (AML), two for acute lymphocytic leukemia (ALL) and nine for CML. After a median follow up of 16 years, five patients (15.6%) are alive in remission (one from chemotherapy group and four from SCT group). Conclusions Our report lends credence to the safety and feasibility of administering anti-leukemic therapy in acute and chronic leukemias during pregnancy although acute leukemia patients had possibly a poor long term outcome compared to non-pregnant patients. © 2014 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Saleh, Abu Jafar Mohammed
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Alhejazi, Ayman Yahya
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ahmed, Syed Osman Ali
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Mohareb, Fahad I.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Sharif, Fahad Z.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Zahrani, Hazzaa Abdulla
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Mohamed, Said Yousuf
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Rasheed, Walid
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Aldawsari, Ghuzayel
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ibrahim, Khalid El Tayeb
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ahmed, Shad O.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Chebbo, Wahiba
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
ElGohary, Ghada M.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Almahayni, Muhamad
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Chaudhri, Naeem Arshad
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Aljurf, Mahmoud Deeb
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 26
Authors: 16
Affiliations: 1
Identifiers
Doi:
10.1016/j.hemonc.2014.03.001
ISSN:
16583876
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study