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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Early and nonreversible decrease of CD161++/MAIT cells in HIV infection
Blood, Volume 121, No. 6, Year 2013
Notification
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Description
HIV infection is associated with immune dysfunction, perturbation of immune-cell subsets and opportunistic infections. CD161++CD8 + T cells are a tissue-infiltrating population that produce IL17A, IL22, IFNγ, and TNFα, cytokines important in mucosal immunity. In adults they dominantly express the semi-invariant TCR Vα7.2, the canonical feature of mucosal associated invariant T (MAIT) cells and have been recently implicated in host defense against pathogens. We analyzed the frequency and function of CD161++/MAIT cells in peripheral blood and tissue from patients with early stage or chronic-stage HIV infection. We show that the CD161++/MAIT cell population is significantly decreased in early HIV infection and fails to recover despite otherwise successful treatment. We provide evidence that CD161++/MAIT cells are not preferentially infected but may be depleted through diverse mechanisms including accumulation in tissues and activation-induced cell death. This loss may impact mucosal defense and could be important in susceptibility to specific opportunistic infections in HIV. © 2013 by The American Society of Hematology.
Authors & Co-Authors
Cosgrove, Cormac P.
United Kingdom, Royston
National Institute for Health and Care Research
Ussher, James E.
United Kingdom, Royston
National Institute for Health and Care Research
Rauch, Andri
Switzerland, Bern
University of Bern
Gärtner, Kathleen
United Kingdom, Edinburgh
Ashworth Laboratories
Kurioka, Ayako
United Kingdom, Royston
National Institute for Health and Care Research
Kang, Yuhoi
United Kingdom, Royston
National Institute for Health and Care Research
Fergusson, Joannah R.
United Kingdom, Royston
National Institute for Health and Care Research
Simmonds, Peter N.
United Kingdom, Edinburgh
Ashworth Laboratories
Goulder, Philip Jeremy Renshaw
United Kingdom, Royston
National Institute for Health and Care Research
Fox, Julie Meriel
United Kingdom, London
Faculty of Life Sciences & Medicine
Günthard, Hüldrych Fritz
Switzerland, Zurich
Universität Zürich
Khanna, Nina
Switzerland, Basel
Universitätsspital Basel
Powrie, Fiona M.
United Kingdom, Oxford
University of Oxford
Steel, Alan W.
United Kingdom, London
Chelsea and Westminster Hospital
Gazzard, Brian George L.
United Kingdom, London
Chelsea and Westminster Hospital
Phillips, Rodney E.
United Kingdom, Royston
National Institute for Health and Care Research
Frater, John
United Kingdom, Royston
National Institute for Health and Care Research
Uhlig, Holm H.
United Kingdom, Oxford
University of Oxford
Klenerman, Paul
United Kingdom, Royston
National Institute for Health and Care Research
Statistics
Citations: 255
Authors: 19
Affiliations: 9
Identifiers
Doi:
10.1182/blood-2012-06-436436
ISSN:
00064971
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study