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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain
Pharmacological Research, Volume 46, No. 3, Year 2002
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Description
Oxidative stress is believed to be implicated in the pathogenesis of postischaemic cerebral injury. Many antioxidants were shown to be neuroprotective in experimental models of cerebral ischaemia/reperfusion (I/R). The present study was designed to investigate the potential protective effects of curcumin (CUR) against I/R insult in rat forebrain. The model adopted was that of surgically-induced forebrain ischaemia, performed by means of bilateral common carotid artery occlusion (BCCAO) for 1 h, followed by reperfusion for another 1 h. The effects of a single i.p. dose of CUR (50, 100 or 200 mg kg-1), administered 0.5 h after the onset of ischaemia, were investigated by assessing oxidative stress-related biochemical parameters in rat forebrain. CUR, at the highest dose level (200 mg kg-1), decreased the I/R-induced elevated xanthine oxidase (XO) activity, superoxide anion (O2•-) production, malondialdehyde (MDA) level and glutathione peroxidase (GPx), superoxide dismutase (SOD), and lactate dehydrogenase (LDH) activities. On the other hand, CUR did not affect the declined reduced glutathione (GSH) content due to I/R insult. Worth mentioning is that the activity of catalase (CAT) did not change in response to either I/R insult or drug treatment. In conclusion, CUR was found to protect rat forebrain against I/R insult. These protective effects may be attributed to its antioxidant properties and/or its inhibitory effects on xanthine dehydrogenase/xanthine oxidase (XD/XO) conversion and resultant O2•-) production. © 2002 Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Ghoneim, Asser Ibrahim
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Abdel-Naim, Ashraf Bahyeldeen
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Khalifa, Amani E.
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
El-Denshary, E. S.M.
Egypt, Cairo
Faculty of Pharmacy
Statistics
Citations: 196
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/S1043-6618(02)00123-8
ISSN:
10436618
Research Areas
Violence And Injury