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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Screening of the fruit pulp extract of Momordica balsamina for anti HIV property
African Journal of Biotechnology, Volume 6, No. 1, Year 2007
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Description
Anti-HIV properties of the fruit pulp extract of Momordica balsamina, a plant of the cucurbitacea family commonly used in the Northern part of Nigeria for its anti-viral efficacy in poultry, was studied in vitro. Peripheral blood mononuclear cells (PBMCs) were prepared from both HIV sero positive and sero negative patients and categorized into group A (sero negative), group B (PBMC co-culture), group C (PBMC co-culture containing 3.12 mg/ml of the plant extract) and group D (only the enriched culture medium). The PBMCs were cultivated for 28 days using standard methods. CD4+ counts and virus detection assay (P24) were determined on the PBMC. Results showed that the plant extract treatment significantly (P<0.05) increased the CD4+ count when compared to the untreated PBMC, a contrary effect was observed on the P 24 antigen level (P<0.05). The implication of these findings is discussed. © 2007 Academic Journals.
Authors & Co-Authors
And, Bot Y.S.
Nigeria, Jos
Plateau State Specialist Hospital
Mgbojikwe, Levi O.
Unknown Affiliation
Nwosu, Chika
Nigeria, Vom
National Veterinary Research Institute, Vom
Abimiku, Alash'Le G.
United States, Baltimore
Institute of Human Virology
Dadik, Jelpe
Nigeria, Jos
Plateau State Human Virology Research Center Plasvirec
Damshak, Demas
Nigeria, Jos
Plateau State Human Virology Research Center Plasvirec
Statistics
Citations: 6
Authors: 6
Affiliations: 4
Identifiers
e-ISSN:
16845315
Research Areas
Infectious Diseases
Study Locations
Nigeria