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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Quetiapine v. lithium in the maintenance phase following a first episode of mania: Randomised controlled trial
British Journal of Psychiatry, Volume 210, No. 6, Year 2017
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Description
Background Lithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their efficacy compares with each other. Aims To investigate the differential effect of lithium and quetiapine on symptoms of depression, mania, general functioning, global illness severity and quality of life in patients with recently stabilised first-episode mania. Method Maintenance trial of patients with first-episode mania stabilised on a combination of lithium and quetiapine, subsequently randomised to lithium or quetiapine monotherapy (up to 800 mg/day) and followed up for 1 year. (Trial registration: Australian and New Zealand Clinical Trials Registry - ACTRN12607000639426.) Results In total, 61 individuals were randomised. Within mixed-model repeated measures analyses, significant omnibus treatment6visit interactions were observed for measures of overall psychopathology, psychotic symptoms and functioning. Planned and post hoc comparisons further demonstrated the superiority of lithium treatment over quetiapine. Conclusions In people with first-episode mania treated with a combination of lithium and quetiapine, continuation treatment with lithium rather than quetiapine is superior in terms of mean levels of symptoms during a 1-year evolution. © The Royal College of Psychiatrists 2017.
Authors & Co-Authors
Berk, Michael
Australia, Geelong
Barwon Health
Australia, Melbourne
Orygen Youth Health
Dandash, Orwa
Australia, Melbourne
Melbourne Health
Yücel, Murat
Australia, Melbourne
Melbourne Health
Pantelis, Christos S.
Australia, Melbourne
Melbourne Health
Conus, Philippe O.
Switzerland, Lausanne
Université de Lausanne Unil
McGorry, Patrick D.
Australia, Melbourne
Orygen Youth Health
Cotton, Sue M.
Australia, Melbourne
Orygen Youth Health
Statistics
Citations: 46
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1192/bjp.bp.116.186833
ISSN:
00071250
Research Areas
Disability
Mental Health
Study Design
Randomised Control Trial