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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo
IUBMB Life, Volume 64, No. 7, Year 2012
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Description
Ovarian cancer (OC) is one of the most lethal gynaecological cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown that several nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the treatment of OC. Furthermore, we have previously described the molecular mechanisms of NSAIDs' induction of cancer apoptosis. In this report, we evaluated various structurally distinct NSAIDs for their efficacies in inducing apoptosis in nonproliferating OC cells. Although several NSAIDs-induced apoptosis, Flufenamic Acid, Flurbiprofen, Finasteride, Celocoxib, and Ibuprofen were the most potent NSAIDs inducing apoptosis. A combination of these agents resulted in an enhanced effect. Furthermore, we demonstrate that the combination of Flurbiprofen, which targets nonproliferative cells, and Sulindac Sulfide, that affects proliferative cells, strongly reduced tumor growth when compared with a single agent treatment. Our data strongly support the hypothesis that drug treatment regimens that target nonproliferating and proliferating cells may have significant efficacy against OC. These results also provide a rationale for employing compounds or even chemically modified NSAIDs, which selectively and efficiently induce apoptosis in cells during different stages of the cell cycle, to design more potent anticancer drugs. Copyright © 2012 Wiley Periodicals, Inc.
Authors & Co-Authors
Duncan, Kristal C.
South Africa, Cape Town
International Center for Genetic Engineering and Biotechnology Icgeb
Uwimpuhwe, H.
South Africa, Cape Town
International Center for Genetic Engineering and Biotechnology Icgeb
South Africa, Cape Town
Faculty of Health Sciences
Czibere, Akos
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
United States, Boston
Harvard Medical School
Sarkar, Devanand
United States, Richmond
Virginia Commonwealth University
Libermann, Towia Aron
United States, Boston
Harvard Medical School
Fisher, Paul B.
United States, Richmond
Virginia Commonwealth University
Zerbini, Luiz Fernando
South Africa, Cape Town
International Center for Genetic Engineering and Biotechnology Icgeb
South Africa, Cape Town
Faculty of Health Sciences
Statistics
Citations: 28
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1002/iub.1035
ISSN:
15216543
e-ISSN:
15216551
Research Areas
Cancer
Study Design
Cross Sectional Study