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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Hepatitis B and C in Juba, southern Sudan: Results of a serosurvey
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 88, No. 5, Year 1994
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Description
To compare the epidemiology of hepatitis B virus (HBV) with hepatitis C virus (HCV) in a southern Sudanese population, 666 out-patients attending 6 public clinics in the city of Juba were enrolled in a serosurvey. The average age of subjects was 16 years; 54% were female. Of the 651 samples tested for hepatitis B markers, HBsAg was found in 26% and anti-HBc in 67%. In contrast, only 21 (3%) of the 666 samples were positive for anti-HCV using a second generation immunoblot assay (RIBA-2). Seventeen (81%) of the 21 anti-HCV-positive subjects were positive for anti-HBc, compared to 66% (418/630) of subjects negative for anti-HCV (P = 0·07). None of the anti-HCV-positive subjects reported receiving a prior blood transfusion and only 5 subjects reported a history of jaundice. Nine of the 21 (43%) anti-HCV-positive subjects reported a history of scarification, compared to 23% (148/645) of anti-HCV-negative subjects (P = 0·01). Hepatitis B infection was also associated with scarification by univariate analysis. However, after adjustment for age a history of scarification was not significantly associated with hepatitis C infection, but it was with HBV infection (odds ratio = 1·5, 95% CI 1·0–2·5; P = 0·05). The findings of this study indicate that HCV infection is not highly endemic in this population and that the epidemiology of HCV differs from that of HBV. © 1994 Oxford University Press.
Authors & Co-Authors
Mc Carthy, Michael C.
Egypt, Cairo
Us Naval Medical Research Unit
El-Tigani, Ahmed
Sudan, Khartoum
Federal Ministry of Health Sudan
Khalid, Ismail O.
Sudan, Khartoum
Federal Ministry of Health Sudan
Hyams, Kenneth Craig
United States, Bethesda
Naval Medical Research Institute, Bethesda
Statistics
Citations: 56
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/0035-9203(94)90150-3
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Sudan
Participants Gender
Female