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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: Anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles
British Journal of Dermatology, Volume 161, No. 3, Year 2009
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Description
Background Pemphigus foliaceus is an autoimmune blistering skin disease that partly results from genetic factors, especially human leucocyte antigen (HLA) class II genes. Objectives The aim of the study was to determine the HLA DR/DQ markers of susceptibility and protection in the Tunisian endemic form. Methods Genomic DNA from 90 patients with pemphigus foliaceus recruited from all parts of the country and matched by age, sex and geographical origin with 270 healthy individuals, was genotyped. Results Firstly, when the whole patient population was studied, DRB1*03, DQB1*0302 and DRB1*04 alleles were significantly associated with the disease while a significant decrease of, in particular, DRB1*11 and DQB1*0301 was observed in patients compared with controls. DRB1*0301 was the dominant allele in DR3-positive patients and controls, while DRB1*0402 was found in 42% of DR4-positive patients. Secondly, when the HLA DR/DQ allele distribution was studied after dividing patients according to their geographical origin, the southern group, which consisted exclusively of patients with the endemic form of the disease, showed the same associations as the whole pemphigus foliaceus population, particularly with DRB1*03. In the northern group, only the DRB1*04 and DQB1*0301 alleles were found to be associated. Interestingly, anti-desmoglein 1 antibody-positive healthy controls did not carry susceptibility alleles but, in contrast, most carried negatively associated alleles. Conclusions These observations indicate that a particular genetic background characterizes the Tunisian endemic form of pemphigus foliaceus and that HLA class II genes control the pathogenic properties of the autoimmune response rather than the initial breakage of B-cell tolerance. © 2009 British Association of Dermatologists.
Authors & Co-Authors
Abida, Olfa
Tunisia, Sfax
Chu Habib Bourguiba
Zitouni, Mondher
Tunisia, Tunis
Hôpital la Rabta
Kallel-Sellami, Marayam
Tunisia, Tunis
Hôpital la Rabta
Mahfoudh, Nadia
Tunisia, Sfax
Chu Hedi-chaker
Kamoun, Arwa
Tunisia, Sfax
Chu Hedi-chaker
Ben-Ayed, Mourad
Tunisia, Sfax
Chu Habib Bourguiba
Masmoudi, Abderrahmane
Tunisia, Sfax
Chu Hedi-chaker
Mokni, Mourad
Tunisia, Tunis
Hôpital la Rabta
Fezzaa, B.
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Ben-Osman, Amel
Tunisia, Tunis
Hôpital la Rabta
Kammoun, Mohamed Ridha
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Turki, Hamaida
Tunisia, Sfax
Chu Hedi-chaker
Makni, Hafedh
Tunisia, Sfax
Chu Hedi-chaker
Gilbert, Danieèle
France, Rouen
Panther - Physiopathologie, Autoimmunité, Maladies Neuromusculaires et Therapies Régénératrices
Joly, Pascal
France, Rouen
Panther - Physiopathologie, Autoimmunité, Maladies Neuromusculaires et Therapies Régénératrices
Tron, Françcois
France, Rouen
Panther - Physiopathologie, Autoimmunité, Maladies Neuromusculaires et Therapies Régénératrices
Makni, Soundes
Tunisia, Tunis
Hôpital la Rabta
Masmoudi, Hatem
Tunisia, Sfax
Chu Habib Bourguiba
Statistics
Citations: 47
Authors: 18
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-2133.2009.09207.x
ISSN:
00070963
e-ISSN:
13652133
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study