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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia
American Journal of Hematology, Volume 76, No. 3, Year 2004
Notification
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Description
The prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations were investigated among 87 Saudi sickle cell disease (SCD) patients (38 males and 49 females) and 105 healthy controls (65 males and 40 females). The prevalences of factor V Leiden (P = 0.174) and PRT G20210A (P = 0.397) were not different between patients and controls, thereby giving no support to an association of either single-point mutation with SCD. However, an increased prevalence of the MTHFR 677 T/T genotype was seen among patients (8/87) compared to controls (4/105), but this was not statistically significant (P = 0.217; OR = 2.56). This suggested a low impact of inherited hypercoagulability risk factors in the pathogenesis of SCD and/or its complications. © 2004 Wiley-Liss, Inc.
Authors & Co-Authors
Fawaz, Naglaa A.
Saudi Arabia, Dammam
Imam Abdulrahman Bin Faisal University
Bashawri, Layla Abdullmohsen M.
Saudi Arabia, Dammam
Imam Abdulrahman Bin Faisal University
Al-Sheikh, Iman
Saudi Arabia, Dammam
Imam Abdulrahman Bin Faisal University
Qatari, Ahlam
Saudi Arabia, Dammam
Imam Abdulrahman Bin Faisal University
Al-Othman, Sara S.
Bahrain, Manama
Arabian Gulf University
Almawi, Wassim Y.
Bahrain, Manama
Arabian Gulf University
Statistics
Citations: 27
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1002/ajh.20087
ISSN:
03618609
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Participants Gender
Female