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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Immunophenotypic lymphocyte profiles in human African trypanosomiasis
PLoS ONE, Volume 4, No. 7, Article e6184, Year 2009
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Description
Human African trypanosomiasis (HAT) is a deadly vector-born disease caused by an extracellular parasite, the trypanosome. Little is known about the cellular immune responses elicited by this parasite in humans. We used multiparameter flow cytometry to characterize leukocyte immunophenotypes in the blood and cerebrospinal fluid (CSF) of 33 HAT patients and 27 healthy controls identified during a screening campaign in Angola and Gabon. We evaluated the subsets and activation markers of B and T lymphocytes. Patients had a higher percentage of CD19+ B lymphocytes and activated B lymphocytes in the blood than did controls, but lacked activated CD4+ T lymphocytes (CD25+). Patients displayed no increase in the percentage of activated CD8+ T cells (HLA-DR+, CD69+ or CD25+), but memory CD8 T-cell levels (CD8+CD45RA-) were significantly lower in patients than in controls, as were effector CD8 T-cell levels (CD8+CD45RA+CD62L-). No relationship was found between these blood immunophenotypes and disease severity (stage 1 vs 2). However, CD19+ B-cell levels in the CSF increased with disease severity. The patterns of T and B cell activation in HAT patients suggest that immunomodulatory mechanisms may operate during infection. Determinations of CD19+ B-cell levels in the CSF could improve disease staging. © 2009 Boda et al.
Authors & Co-Authors
Boda, Caroline
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Courtioux, Bertrand
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Roques, Pierre A.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Fontenay-aux-roses
Cea Fontenay Aux Roses
Pervieux, Lynda
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Vatunga, Gedeão M.L.
Angola, Luanda
Instituto de Combate e Controlo Das Tripanossomiases
Josénando, Théophile
Angola, Luanda
Instituto de Combate e Controlo Das Tripanossomiases
Ayenengoye, Constant Roger
Gabon
Pnltha
Bouteille, Bernard
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Jauberteau-Marchan, M. O.
France, Limoges
Homéostasie Cellulaire et Pathologies
Bisser, Sylvie
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Statistics
Citations: 13
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0006184
e-ISSN:
19326203
Study Locations
Angola
Gabon