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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Cadmium-induced oxidative stress and DNA damage in kidney of pregnant female rats
Comptes Rendus - Biologies, Volume 331, No. 6, Year 2008
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Description
In the present study, we have investigated the influence of sub-acute treatment with cadmium (Cd) on some parameters indicative of oxidative stress and DNA damage in tissues of pregnant female rats. Pregnant female rats (n = 6) were injected subcutaneously, daily with a dose of cadmium chloride of 3 mg/kg body weight (b.w.) from day 6 to day 19 of pregnancy, and they were allowed to deliver normally. MDA level and GPx, CAT and SOD activities were used as markers of oxidative stress in liver and kidney. The 8-oxo-dG level was measured by the HPLC-EC system. Cd treatment increased MDA (+116%, p < 0.01) in kidney. Moreover, Cd treatment also decreased CuZn-SOD (-11%, p < 0.05) and GSH level (-52%, p < 0.05) in kidney. Treated rats displayed an increase of the liver metallothionein (MT) level. Induction of MT in liver was probably implicated in the detoxification of Cd. The high level of Cd (3 mg/kg) used in the present study is partially neutralized by MT in liver, whereas the free fraction could be implicated in the oxidative stress and DNA oxidation observed in kidney. Cd treatment failed to alter 8-oxodGuo, indicating the absence of DNA oxidation in liver; by contrast, the same treatment increased the 8-oxodGuo level (+51%, p < 0.05) in the kidney of pregnant female rats, indicating an oxidative stress associated with DNA damage only in kidney. To cite this article: S. Chater et al., C. R. Biologies 331 (2008). © 2008 Académie des sciences.
Authors & Co-Authors
Chater, Sihem
Tunisia, Tunis
University of Carthage
France, Grenoble
Scib
France, La Tronche
Hôpital de la Tronche Chu Grenoble
Douki, Thierry
France, Grenoble
Scib
Garrel, Catherine
France, La Tronche
Hôpital de la Tronche Chu Grenoble
Favier, Alain Emile
France, Grenoble
Scib
France, La Tronche
Hôpital de la Tronche Chu Grenoble
Sakly, Mohsen
Tunisia, Tunis
University of Carthage
Abdelmelek, Hafedh
Tunisia, Tunis
University of Carthage
Statistics
Citations: 46
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.crvi.2008.03.009
ISSN:
16310691
Research Areas
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female