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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Mechanisms of enhanced antigen-specific T cell response following vaccination with a novel peptide-based cancer vaccine and systemic interleukin-2 (IL-2)
Vaccine, Volume 21, No. 19-20, Year 2003
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Description
Systemic interleukin-2 (IL-2) therapy has been shown to enhance the clinical efficacy of peptide-based cancer vaccines. However, the mechanisms involved in this complex response remain poorly defined. IL-2 is known to be a potent T cell growth factor, but recent studies suggest that IL-2 is also involved in the regulation of T cell immune responses by increasing the susceptibility of proliferating T cells to apoptosis. Using an adoptive transfer model, we demonstrate that the administration of systemic IL-2 significantly enhances the primary and memory immune responses following peptide-based vaccination. In order to define the mechanisms of IL-2 therapy on the antigen-specific T cell response, the kinetics of T cell proliferation, apoptosis, and trafficking were explored. Systemic IL-2 therapy did not appear to alter the kinetics of T cell proliferation immediately following vaccination, but did prolong the proliferative response. Furthermore, IL-2 therapy did not significantly influence apoptosis of proliferating T cells. Such therapy did, however, potentiate L-selectin (CD62L) downregulation on activated antigen-specific T cells, and altered their trafficking confirming their potential therapeutic value. Our findings support the use of systemic IL-2 following peptide-based vaccination, and suggest that IL-2 therapy enhances the primary and memory immune responses by prolonging the proliferative response and altering the trafficking of antigen-specific T cells. © 2003 Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Salem, Mohamed Labib
United States, Charleston
Medical University of South Carolina
Rubinstein, Mark P.
United States, Charleston
Medical University of South Carolina
Demcheva, Marina V.
United States, Charleston
Medical University of South Carolina
Vournakis, John N.
United States, Charleston
Medical University of South Carolina
Cole, David J.
United States, Charleston
Medical University of South Carolina
Statistics
Citations: 25
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1016/S0264-410X(03)00096-3
ISSN:
0264410X
Research Areas
Cancer