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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids
Food and Chemical Toxicology, Volume 49, No. 5, Year 2011
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Description
This study was conducted to investigate the effect of curcumin, obtained from Curcuma longa, in comparison with rosiglitazone on the progression of insulin resistance and type 2 diabetes mellitus (T2DM) and the mechanisms underlying this effect. Insulin resistance and T2DM was induced in male Sprague Dawley rats by high fat diet (HFD) feeding for 60 and for 75. days representing two regimens of the study, protection and treatment. Prophylactic oral administration of curcumin (80. mg/kg), rosiglitazone (1. mg/kg), their combination, or vehicle (in control groups) was started along with HFD feeding in different groups. Treatment is achieved by oral administration of the previously mentioned agents in the last 15. days of HFD feeding after induction of insulin resistance and T2DM in rats. Curcumin showed an anti-hyperglycemic effect and improved insulin sensitivity, and this action may be attributed at least in part to its anti-inflammatory properties as evident by attenuating TNF-α levels in HFD fed rats, and its anti-lipolytic effect as evident by attenuating plasma free fatty acids. The curcumin effects are comparable to those of rosiglitazone, which indicate that they may act similarly. Finally we can say that, curcumin could be a beneficial adjuvant therapy in patients with T2DM. © 2011 Elsevier Ltd.
Authors & Co-Authors
El-Moselhy, Mohamed Ahmed M.
Egypt, Minya
Faculty of Pharmacy
Taye, Ashraf Mohamed
Egypt, Minya
Faculty of Pharmacy
Sharkawi, Sara Shaaban
Egypt, Minya
Faculty of Pharmacy
El-Sisi, Suzan F.I.
Egypt, Cairo
National Organization for Drug Control and Research Egypt
Ahmed, Ahmed Fahmy
Egypt, Zagazig
Faculty of Pharmacy
Statistics
Citations: 189
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.fct.2011.02.004
ISSN:
02786915
Research Areas
Health System And Policy
Noncommunicable Diseases
Participants Gender
Male