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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution
Open Forum Infectious Diseases, Volume 9, No. 7, Article ofac192, Year 2022
Notification
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Description
Background: The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals and the potential for vaccinated individuals to transmit the virus. Methods: We examined viral dynamics and infectious virus shedding through daily longitudinal sampling in 23 adults infected with SARS-CoV-2 at varying stages of vaccination, including 6 fully vaccinated individuals. Results: The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases. Conclusions: Vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination. © 2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9047214/bin/ofac192_supplementary_data.pdf
Authors & Co-Authors
Ke, Ruian
United States, Los Alamos
Los Alamos National Laboratory
Smith, Rebecca Lee
United States, Urbana
University of Illinois Urbana-champaign
Gibson, Laura L.
United States, Worcester
University of Massachusetts Chan Medical School
Achenbach, Chad J.
United States, Worcester
University of Massachusetts Chan Medical School
United States, Chicago
Northwestern University Feinberg School of Medicine
McFall, Sally M.
United States, Evanston
Northwestern University
Qi, Chao
United States, Chicago
Northwestern University Feinberg School of Medicine
Dembele, Etienne
United States, Chicago
Northwestern University Feinberg School of Medicine
Simons, Lacy M.
United States, Chicago
Northwestern University Feinberg School of Medicine
Ozer, Egon Anderson
United States, Chicago
Northwestern University Feinberg School of Medicine
Hultquist, Judd F.
United States, Chicago
Northwestern University Feinberg School of Medicine
Lorenzo-Redondo, Ramón
United States, Chicago
Northwestern University Feinberg School of Medicine
Hawkins, Claudia A.
United States, Chicago
Northwestern University Feinberg School of Medicine
Murphy, Robert L.
United States, Chicago
Northwestern University Feinberg School of Medicine
Gallagher, Nicholas D.
United States, Baltimore
Johns Hopkins School of Medicine
Luo, Chunhuai
United States, Baltimore
Johns Hopkins School of Medicine
Conte, Abigail R.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Rendon, Gloria
United States, Urbana
University of Illinois Urbana-champaign
Fields, Christopher J.
United States, Urbana
University of Illinois Urbana-champaign
Wang, Leyi
United States, Urbana
University of Illinois Urbana-champaign
Chiu, Karen K.
United States, Urbana
University of Illinois Urbana-champaign
Barton, Bruce A.
United States, Worcester
University of Massachusetts Chan Medical School
Robinson, Matthew L.
United States, Worcester
University of Massachusetts Chan Medical School
United States, Baltimore
Johns Hopkins School of Medicine
Mostafa, Heba H.
United States, Baltimore
Johns Hopkins School of Medicine
Manabe, Yukari C.
United States, Worcester
University of Massachusetts Chan Medical School
United States, Baltimore
Johns Hopkins School of Medicine
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Pekosz, Andrew S.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 16
Authors: 25
Affiliations: 8
Identifiers
Doi:
10.1093/ofid/ofac192
ISSN:
23288957
Research Areas
Covid
Study Design
Cohort Study