Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Performance metrics after changes in screening protocol for congenital hypothyroidism
Pediatrics, Volume 130, No. 5, Year 2012
Notification
URL copied to clipboard!
Description
OBJECTIVE: To evaluate Michigan newborn screening for congenital hypothyroidism (CH) protocol changes. METHODS: This population-based study includes infants born and screened in Michigan (January 1, 1994-June 30, 2010). Screening performance is compared across 4 periods defined by the dried blood spot testing method: (1) thyroxine (T4) with backup thyrotropin, (2) tandem T4 and thyrotropin, (3) primary thyrotropin testing without serial testing, and (4) primary thyrotropin plus serial testing for births weighing <1800 g. Logistic regression is used to test for differences across periods. RESULTS: Thyrotropin testing exhibited greater specificity overall and greater likelihood of detection with serial testing relative to primary T4 testing. Tandem T4 and thyrotropin testing appeared more sensitive relative to other protocols, yet it produced significantly more false-positives, and detection may have been affected by overdiagnosis and misclassification. Central CH was no longer detected once T4 testing ceased. CONCLUSIONS: Primary thyrotropin plus serial testing for infants at risk for later rising thyrotropin outperformed other newborn screening strategies for classic CH, although 2 false-negatives occurred among normal birth weight infants admitted to the NICU during this testing period. Tandem T4 and thyrotropin screening outperformed other strategies for detection of both classic and central CH combined, although it is associated with increased operating costs. Additional research is necessary to weigh the benefits of increased sensitivity against additional program operating costs. Copyright © 2012 by the American Academy of Pediatrics.
Authors & Co-Authors
Birbeck, Gretchen Lano
United States, East Lansing
Michigan State University
Todem, David
United States, East Lansing
Michigan State University
Romero, Roberto J.
United States, Bethesda
National Institutes of Health Nih
Chaiworapongsa, Tinnakorn
United States, Bethesda
National Institutes of Health Nih
United States, Detroit
Wayne State University
Paneth, Nigel S.
United States, East Lansing
Michigan State University
Statistics
Citations: 6
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1542/peds.2011-3340
ISSN:
10984275
Study Design
Cross Sectional Study