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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Total plasma clearance of cr-edta: variation with age and sex in normal adults
Nuclear Medicine Communications, Volume 21, No. 2, Year 2000
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Description
Although inulin clearance measured during constant infusion is still considered the reference method, single-injection of Cr-EDTA with subsequent plasma sampling has become the most popular technique for the routine assessment of glomerular filtration rate. Despite the fact that the technique has been in use for 30 years, there are only a few reports of normal values calculated directly from Cr-EDTA data and normal ranges have generally been produced by conversions of inulin data. The aim of this study was to measure the variation in total plasma clearance, calculated directly from Cr-EDTA measurements, in normal males and females, of Saudi Arabian origin, over a wide range. Altogether, 201 potential kidney donors aged 16-60 years were studied. No statistically significant association of total plasma clearance with age or sex could be demonstrated; however, predictive equations suggesting a small decline in total plasma clearance with age were developed. The figures presented suggest that the reduction in total plasma clearance of Cr-EDTA with age is relatively shallow up to the age of at least 60 years and that normal ranges produced by conversion of inulin data may overestimate the decline with age. © 2000 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Hamilton, David
Saudi Arabia, Riyadh
Riyadh Military Hospital
Riley, Peter J.
Saudi Arabia, Riyadh
Riyadh Military Hospital
Miola, Ueber J.
Saudi Arabia, Riyadh
Riyadh Military Hospital
Mousa, Dujanah Hassan
Saudi Arabia, Riyadh
Riyadh Military Hospital
Popovich, William
Saudi Arabia, Riyadh
Riyadh Military Hospital
Al-Khader, Abdullah Ahmed
Saudi Arabia, Riyadh
Riyadh Military Hospital
Statistics
Citations: 29
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1097/00006231-200002000-00011
ISSN:
01433636
e-ISSN:
14735628
Participants Gender
Female