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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A useful high‐dose intermittent schedule of adriamycin and DTIC in the treatment of advanced sarcomas
Cancer, Volume 58, No. 10, Year 1986
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Description
One‐hundred‐fourteen evaluable patients with metastatic soft tissue or bony sarcoma with measurable disease were treated with Adriamycin (doxorubicin) administered intravenously at a dose of 60 mg/M2on day 1, followed by DTIC (dacarbazine) at a dose of 750 mg/M2; courses were administered at 3‐week intervals. Ten complete remissions and 17 partial remissions were observed. The most responsive cell type was malignant fibrous histiocytoma with a response rate of 54%. This treatment schedule was very well tolerated, with only moderate myelosuppression and moderate nausea and vomiting. Cardiac toxicity was identified in three patients, with two patients demonstrating electrocardiogram (EKG) changes and arrhythmias and only one patient developing heart failure. The 24% overall response rate suggests no compromise in activity on this schedule, with a significant reduction in toxicity. Copyright © 1986 American Cancer Society
Authors & Co-Authors
Saiki, John
Unknown Affiliation
Baker, Laurence H.
Unknown Affiliation
Rivkin, Saul Eugene
Unknown Affiliation
Shahbender, Salah
Unknown Affiliation
Fletcher, William
Unknown Affiliation
Athens, John
Unknown Affiliation
Balcerzak, Stanley P.
Unknown Affiliation
Bonnet, John D.
Unknown Affiliation
Statistics
Citations: 15
Authors: 8
Affiliations: 9
Identifiers
Doi:
10.1002/1097-0142(19861115)58:10<2196::AID-CNCR2820581005>3.0.CO;2-J
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Health System And Policy
Noncommunicable Diseases