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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal Kenya
Vaccine, Volume 24, No. 19, Year 2006
Notification
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Description
The merozoite surface protein (MSP) 2 is a vaccine candidate antigen of Plasmodium falciparum that is polymorphic in natural populations. In a prospective cohort study in two coastal populations of Kenya using recombinant proteins derived from the two major allelic types of MSP2, high serum levels of IgG to MSP2 were associated with protection from clinical malaria. This protection was independent of that associated with antibodies to another vaccine candidate antigen (AMA1) in these populations. However, low antibody levels to MSP2 appeared to be associated with increased susceptibility to malaria within people who were parasite negative at the time of serum collection. These data suggest that an MSP2 based vaccine should be designed to induce high level antibody responses against the different MSP2 types present globally in P. falciparum populations and that MSP2 could be combined with other P. falciparum antigens to form a multi-component malaria vaccine. © 2005 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Polley, Spencer D.
Unknown Affiliation
Conway, David J.
Unknown Affiliation
Cavanagh, David R.
Unknown Affiliation
McBride, Jana S.
Unknown Affiliation
Lowe, Brett S.
Unknown Affiliation
Williams, Thomas Neil
Unknown Affiliation
Mwangi, Tabitha Wanja
Unknown Affiliation
Marsh, Kevin
Unknown Affiliation
Statistics
Citations: 149
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/j.vaccine.2005.06.030
ISSN:
0264410X
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Kenya