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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Population genomics of the immune evasion (var) genes of Plasmodium falciparum
PLoS Pathogens, Volume 3, No. 3, Year 2007
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Description
Var genes encode the major surface antigen (PfEMP1) of the blood stages of the human malaria parasite Plasmodium falciparum. Differential expression of up to 60 diverse var genes in each parasite genome underlies immune evasion. We compared the diversity of the DBLα domain of var genes sampled from 30 parasite isolates from a malaria endemic area of Papua New Guinea (PNG) and 59 from widespread geographic origins (global). Overall, we obtained over 8,000 quality-controlled DBLα sequences. Within our sampling frame, the global population had a total of 895 distinct DBLα "types" and negligible overlap among repertoires. This indicated that var gene diversity on a global scale is so immense that many genomes would need to be sequenced to capture its true extent. In contrast, we found a much lower diversity in PNG of 185 DBLα types, with an average of approximately 7% overlap among repertoires. While we identify marked geographic structuring, nearly 40% of types identified in PNG were also found in samples from different countries showing a cosmopolitan distribution for much of the diversity. We also present evidence to suggest that recombination plays a key role in maintaining the unprecedented levels of polymorphism found in these immune evasion genes. This population genomic framework provides a cost effective molecular epidemiological tool to rapidly explore the geographic diversity of var genes. © 2007 Barry et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.sg001.ppt
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.sg002.ppt
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.sg003.ppt
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.sg004.jpg
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.sg005.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.sg006.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.sg007.ppt
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.st001.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.st002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.sd001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC1828697/bin/ppat.0030034.sd002.doc
Authors & Co-Authors
Barry, Alyssa E.
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Australia, Melbourne
Macfarlane Burnet Institute for Medical Research
Leliwa-Sytek, Aleksandra
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
United States, New York
Nyu Grossman School of Medicine
Tavul, Livingstone
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Imrie, Heather J.
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
Migot-Nabias, Florence
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Marseille
Ird Institut de Recherche Pour le Developpement
Brown, Stuart M.
United States, New York
Nyu Grossman School of Medicine
McVean, Gil
United Kingdom, Oxford
University of Oxford
Day, Karen P.
United Kingdom, Oxford
Nuffield Department of Medicine
United Kingdom, Oxford
University of Oxford
United States, New York
Nyu Grossman School of Medicine
Statistics
Citations: 187
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1371/journal.ppat.0030034
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Guinea