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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion
Nature Communications, Volume 10, No. 1, Article 5315, Year 2019
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Description
To colonise their host, pathogens must counter local environmental and immunological challenges. Here, we reveal that the fungal pathogen Candida albicans exploits diverse host-associated signals to promote immune evasion by masking of a major pathogen-associated molecular pattern (PAMP), β-glucan. Certain nutrients, stresses and antifungal drugs trigger β-glucan masking, whereas other inputs, such as nitrogen sources and quorum sensing molecules, exert limited effects on this PAMP. In particular, iron limitation triggers substantial changes in the cell wall that reduce β-glucan exposure. This correlates with reduced phagocytosis by macrophages and attenuated cytokine responses by peripheral blood mononuclear cells. Iron limitation-induced β-glucan masking depends on parallel signalling via the iron transceptor Ftr1 and the iron-responsive transcription factor Sef1, and the protein kinase A pathway. Our data reveal that C. albicans exploits a diverse range of specific host signals to trigger protective anticipatory responses against impending phagocytic attack and promote host colonisation. © 2019, The Author(s).
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Authors & Co-Authors
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Brown, Gordon D.A.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
United Kingdom, London
Medical Research Council
Erwig, Lars Peter
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
United Kingdom, Brentford
Galvani Bioelectronics
Gow, Neil A.R.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
United Kingdom, London
Medical Research Council
Brown, Alistair J.P.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
United Kingdom, London
Medical Research Council
Statistics
Citations: 51
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1038/s41467-019-13298-9
ISSN:
20411723