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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Reformatsky reactions with N-arylpyrrolidine-2-thiones: Synthesis of tricyclic analogues of quinolone antibacterial agents
Tetrahedron, Volume 57, No. 47, Year 2001
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Description
A convenient synthesis of 5-oxo-1,2,3,5-tetrahydropyrrolo[1,2-α]quinoline-4-carboxylic acids, tricylic analogues of the quinolone antibiotics, is described. Key steps in the route are a novel zinc-mediated Reformatsky reaction between diethyl bromomalonate and N-arylpyrrolidine-2-thione 18, and cyclisation of the resulting diethyl pyrrolidinylidenemalonate intermediates 19 in polyphosphoric acid. The products proved to be devoid of biological activity. © 2001 Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Michael, Joseph P.
South Africa, Johannesburg
University of the Witwatersrand
de Koning, Charles Bernard D.E.
South Africa, Johannesburg
University of the Witwatersrand
Hosken, Gladys D.
South Africa, Johannesburg
University of the Witwatersrand
Stanbury, Trevor V.
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 75
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/S0040-4020(01)00964-4