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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study
eClinicalMedicine, Volume 57, Article 101896, Year 2023
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Description
Background: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. Methods: This prospective cohort study recruited adults who had survived hospitalisation with clinically diagnosed COVID-19 across 35 sites in the UK (PHOSP-COVID). The burden of frailty was objectively measured using Fried's Frailty Phenotype (FFP). The primary outcome was the prevalence of each FFP group—robust (no FFP criteria), pre-frail (one or two FFP criteria) and frail (three or more FFP criteria)—at 5 months and 1 year after discharge from hospital. For inclusion in the primary analysis, participants required complete outcome data for three of the five FFP criteria. Longitudinal changes across frailty domains are reported at 5 months and 1 year post-hospitalisation, along with risk factors for frailty status. Patient-perceived recovery and health-related quality of life (HRQoL) were retrospectively rated for pre-COVID-19 and prospectively rated at the 5 month and 1 year visits. This study is registered with ISRCTN, number ISRCTN10980107. Findings: Between March 5, 2020, and March 31, 2021, 2419 participants were enrolled with FFP data. Mean age was 57.9 (SD 12.6) years, 933 (38.6%) were female, and 429 (17.7%) had received invasive mechanical ventilation. 1785 had measures at both timepoints, of which 240 (13.4%), 1138 (63.8%) and 407 (22.8%) were frail, pre-frail and robust, respectively, at 5 months compared with 123 (6.9%), 1046 (58.6%) and 616 (34.5%) at 1 year. Factors associated with pre-frailty or frailty were invasive mechanical ventilation, older age, female sex, and greater social deprivation. Frail participants had a larger reduction in HRQoL compared with before their COVID-19 illness and were less likely to describe themselves as recovered. Interpretation: Physical frailty and pre-frailty are common following hospitalisation with COVID-19. Improvement in frailty was seen between 5 and 12 months although two-thirds of the population remained pre-frail or frail. This suggests comprehensive assessment and interventions targeting pre-frailty and frailty beyond the initial illness are required. Funding: UK Research and Innovation and National Institute for Health Research. © 2023 The Author(s)
Authors & Co-Authors
Evans, Rachael Andrea
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Bolton, Charlotte E.
United Kingdom, Nottingham
University of Nottingham
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
United Kingdom, Nottingham
Nottingham Biomedical Research Centre
Brightling, Christopher Edward
Unknown Affiliation
Chalmers, James D.
United Kingdom, Dundee
University of Dundee
Docherty, Annemarie Beth
United Kingdom, Edinburgh
The University of Edinburgh
Harris, Victoria C.
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Harrison, Ewen M.
United Kingdom, Edinburgh
The University of Edinburgh
Horsley, Alexander Robert
United Kingdom, Manchester
The University of Manchester
United Kingdom, Manchester
Manchester University Nhs Foundation Trust
Houchen-Wolloff, Linzy
United Kingdom, Leicester
University of Leicester
United Kingdom, Wakefield
Nhs England
Jolley, Caroline J.
United Kingdom, London
King's College London
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Lone, Nazir Iftikhar
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Nhs Lothian
Marks, Michael E.
United Kingdom, London
London School of Hygiene & Tropical Medicine
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
United Kingdom, London
University College London
Parekh, Dhruv
United Kingdom, Birmingham
University of Birmingham
United Kingdom, Birmingham
University Hospitals Birmingham Nhs Foundation Trust
Quint, Jennifer K.
United Kingdom, London
Imperial College London
Raman, Betty
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
United Kingdom, Oxford
University of Oxford
Richardson, Matthew
Unknown Affiliation
Singh, Sally J.
Unknown Affiliation
Steiner, Michael C.
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Tan, Ai Lyn
United Kingdom, Leeds
University of Leeds
United Kingdom, Leeds
Chapel Allerton Hospital
Wain, Louise V.
United Kingdom, Leicester
University of Leicester
Welch, Carly
United Kingdom, Birmingham
University of Birmingham
Witham, M. D.
United Kingdom, Newcastle
Newcastle University
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Abel, Kathryn M.
Unknown Affiliation
Adeloye, Davies O.
Unknown Affiliation
Adeyemi, Oluwaseun
Unknown Affiliation
Allan, L. M.
Unknown Affiliation
Allen, Richard James
Unknown Affiliation
Almeida, Paula
Unknown Affiliation
Antoniades, Charalambos A.
Unknown Affiliation
Baillie, John Kenneth
Unknown Affiliation
Bain, Stephen C.
Unknown Affiliation
Baldwin, David R.
Unknown Affiliation
Baldwin, Matthew R.
Unknown Affiliation
Ballard, Clive G.
Unknown Affiliation
Banerjee, Amitava
Unknown Affiliation
Batterham, Rachel Louise
Unknown Affiliation
Baxendale, Helen E.
Unknown Affiliation
Bayes, Hannah Kelly
Unknown Affiliation
Beadsworth, Michael B.J.
Unknown Affiliation
Beckett, Paul A.
Unknown Affiliation
Bell, Robert M.
Unknown Affiliation
Bermperi, Areti
Unknown Affiliation
Bhui, Kamaldeep Singh
Unknown Affiliation
Bisnauthsing, Karen N.
Unknown Affiliation
Bramham, Kate
Unknown Affiliation
Breen, Gerome
Unknown Affiliation
Briggs, Andrew M.
Unknown Affiliation
Brown, Julianne S.
Unknown Affiliation
Brown, Michael M.
Unknown Affiliation
Brugha, Traolach Sean
Unknown Affiliation
Brunskill, N. J.
Unknown Affiliation
Burn, David J.
Unknown Affiliation
Burns, Gerard
Unknown Affiliation
Burns, Alistair S.
Unknown Affiliation
Busby, John
Unknown Affiliation
Calder, Philip C.
Unknown Affiliation
Carson, Gail Lindsay
Unknown Affiliation
Casey, Anna L.
Unknown Affiliation
Cassar, Mark Philip
Unknown Affiliation
Chalder, Trudie
Unknown Affiliation
Chalmers, John D.
Unknown Affiliation
Channon, Keith Michael
Unknown Affiliation
Chaudhuri, Nazia
Unknown Affiliation
Chilvers, Edwin R.
Unknown Affiliation
Chinoy, Hector
Unknown Affiliation
Chiribiri, Amedeo
Unknown Affiliation
Chowienczyk, Phil John
Unknown Affiliation
Clohisey, Sara M.R.
Unknown Affiliation
Coleman, Christopher M.
Unknown Affiliation
Connolly, Bronwen A.
Unknown Affiliation
Cooper, D. James
Unknown Affiliation
Coupland, Carol A.C.
Unknown Affiliation
Cullinan, Paul
Unknown Affiliation
Cuthbertson, D. J.
Unknown Affiliation
Daines, Luke
Unknown Affiliation
Dark, Paul M.
Unknown Affiliation
Davies, E. Bethan
Unknown Affiliation
Davies, Melanie J.
Unknown Affiliation
de Soyza, Anthony
Unknown Affiliation
Defres, Sylviane
Unknown Affiliation
Bakerly, Nawar Diar
Unknown Affiliation
Djukanovic, Ratko
Unknown Affiliation
Dong, Tao
Unknown Affiliation
Dormand, Natalie C.
Unknown Affiliation
Easom, Nicholas J.W.
Unknown Affiliation
Edwards, Sarah Louise
Unknown Affiliation
Elmer, Anne
Unknown Affiliation
Evans, David A.
Unknown Affiliation
Felton, Tim W.
Unknown Affiliation
Fisher, Helen L.
Unknown Affiliation
Forton, Daniel M.
Unknown Affiliation
Francis, Susan T.
Unknown Affiliation
Free, Robert C.
Unknown Affiliation
French, N.
Unknown Affiliation
Fuld, Jonathan Paul
Unknown Affiliation
Geddes, John Richard
Unknown Affiliation
George, Jacob
Unknown Affiliation
Gleeson, Fergus V.
Unknown Affiliation
Greenhalf, William
Unknown Affiliation
Gregory, Rebecca
Unknown Affiliation
Haldar, Pranabashis
Unknown Affiliation
Hardwick, Hayley E.
Unknown Affiliation
Hargadon, Beverley
Unknown Affiliation
Hart, Nicholas
Unknown Affiliation
Heaney, Liam G.
Unknown Affiliation
Heeney, Jonathan
Unknown Affiliation
Heightman, Melissa J.
Unknown Affiliation
Heller, Simon R.
Unknown Affiliation
Ho, Ling Pei
Unknown Affiliation
Hosseini, Akram A.
Unknown Affiliation
Hotopf, Matthew Hugo
Unknown Affiliation
Howell, Alice
Unknown Affiliation
Hughes, Rachael A.
Unknown Affiliation
Huneke, Nathan T.M.
Unknown Affiliation
Hurst, John Robert
Unknown Affiliation
Hussell, Tracy
Unknown Affiliation
Jackson, Thomas A.
Unknown Affiliation
Jacob, Joseph
Unknown Affiliation
Johnson, Simon R.
Unknown Affiliation
Jones, Laura L.
Unknown Affiliation
Jones, Mark G.
Unknown Affiliation
Jose, Sherly
Unknown Affiliation
Kamwa, Vicky
Unknown Affiliation
Kerr, Steven
Unknown Affiliation
Khunti, Kamlesh K.
Unknown Affiliation
Klenerman, Paul
Unknown Affiliation
Knight, Sean Blandin
Unknown Affiliation
Kon, Onn Minn
Unknown Affiliation
Kurupati, Prathiba
Unknown Affiliation
Langenberg, Claudia C.
Unknown Affiliation
Lewis, David A.
Unknown Affiliation
Lightstone, Liz
Unknown Affiliation
Lingford-Hughes, Anne R.
Unknown Affiliation
Lipman, Marc CI
Unknown Affiliation
Logan, Sarah A.E.
Unknown Affiliation
Lord, Joanne
Unknown Affiliation
MacGowan, Guy Andrew
Unknown Affiliation
Malim, Michael H.
Unknown Affiliation
Mandal, Swapna
Unknown Affiliation
Mangion, Kenneth
Unknown Affiliation
Manisty, Charlotte H.
Unknown Affiliation
March, Katherine
Unknown Affiliation
Maskell, Nick Anthony
Unknown Affiliation
McArdle, Patrick F.
Unknown Affiliation
McGarvey, Lorcan Patrick Augustine
Unknown Affiliation
McNarry, Melitta A.
Unknown Affiliation
McQueen, Alison
Unknown Affiliation
McShane, Helen
Unknown Affiliation
Mehta, Puja
Unknown Affiliation
Meiring, James E.
Unknown Affiliation
Mills, Nicholas Linton
Unknown Affiliation
Misra, S.
Unknown Affiliation
Molyneaux, Philip L.
Unknown Affiliation
Moss, Alastair James
Unknown Affiliation
Moss, Paul A.H.
Unknown Affiliation
Mukaetova-Ladinska, Elizabeta Blagoja
Unknown Affiliation
Neubauer, Stefan
Unknown Affiliation
Nicholson, Timothy R.
Unknown Affiliation
O'Brien, Caitlin
Unknown Affiliation
O'Regan, Declan P.
Unknown Affiliation
Ogg, Graham Stuart
Unknown Affiliation
Openshaw, Peter J.M.
Unknown Affiliation
Ostermann, Marlies Elizabeth
Unknown Affiliation
Paddick, Stella Maria
Unknown Affiliation
Papineni, Padmasayee
Unknown Affiliation
Pareek, Manish
Unknown Affiliation
Parfrey, Helen
Unknown Affiliation
Pariante, Carmine M.
Unknown Affiliation
Pavlides, Michael
Unknown Affiliation
Pearl, John E.
Unknown Affiliation
Peckham, Daniel Gavin
Unknown Affiliation
Peng, Yanchun
Unknown Affiliation
Peto, Timothy E.A.
Unknown Affiliation
Petousi, Nayia
Unknown Affiliation
Pfeffer, Paul E.
Unknown Affiliation
Pius, Riinu
Unknown Affiliation
Plein, Sven
Unknown Affiliation
Price, Anna
Unknown Affiliation
Rahman, Najib Mahboob
Unknown Affiliation
Ralser, Markus
Unknown Affiliation
Reddy, Raja Vongala
Unknown Affiliation
Ribeiro, Carla G.
Unknown Affiliation
Rivera-Ortega, Pilar
Unknown Affiliation
Roberts, John Keith
Unknown Affiliation
Robinson, Leanne J.
Unknown Affiliation
Rowland-Jones, Sarah Louise
Unknown Affiliation
Rudan, Igor
Unknown Affiliation
Russell, Richard E.K.
Unknown Affiliation
Samani, Nilesh J.
Unknown Affiliation
Sapey, Elizabeth
Unknown Affiliation
Sattar, Naveed
Unknown Affiliation
Saunders, Kate E. A.
Unknown Affiliation
Sayer, A. A.
Unknown Affiliation
Scott, Janet T.
Unknown Affiliation
Semple, Malcolm Gracie
Unknown Affiliation
Shah, Karishma
Unknown Affiliation
Shankar-Hari, Manu
Unknown Affiliation
Shaw, Karen L.
Unknown Affiliation
Sheikh, Aziz
Unknown Affiliation
Sigfrid, Louise A.
Unknown Affiliation
Smith, Susan M.
Unknown Affiliation
Soares, Marcio
Unknown Affiliation
Steiner, Markus F.C.
Unknown Affiliation
Stewart, Iain D.
Unknown Affiliation
Sudlow, Cathie L.M.
Unknown Affiliation
Summers, Charlotte
Unknown Affiliation
Talbot, Nick P.
Unknown Affiliation
Thomas, Sarah R.
Unknown Affiliation
Thompson, A. A.Roger
Unknown Affiliation
Thwaites, Ryan S.
Unknown Affiliation
Tobin, Martin D.
Unknown Affiliation
Toshner, Mark R.
Unknown Affiliation
Touyz, Rhian M.
Unknown Affiliation
Turtle, Lance C.W.
Unknown Affiliation
Valabhji, Jonathan
Unknown Affiliation
Wainwright, Tania
Unknown Affiliation
Wall, Emma C.B.
Unknown Affiliation
Weir-McCall, Jonathan Richard
Unknown Affiliation
Welch, Hugh
Unknown Affiliation
Wessely, Simon Charles
Unknown Affiliation
Wild, Jim M.
Unknown Affiliation
Williams, Nicola C.
Unknown Affiliation
Wilson, Deborah A.
Unknown Affiliation
Wootton, Dan G.
Unknown Affiliation
Wormleighton, Joanne V.
Unknown Affiliation
Worsley, Jieniean
Unknown Affiliation
Wright, Shaney
Unknown Affiliation
Yousuf, Ahmed J.
Unknown Affiliation
Zheng, Bang
Unknown Affiliation
Statistics
Citations: 1
Authors: 229
Affiliations: 26
Identifiers
Doi:
10.1016/j.eclinm.2023.101896
ISSN:
25895370
Research Areas
Covid
Disability
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Female