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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae
Journal of Infectious Diseases, Volume 183, No. 8, Year 2001
Notification
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Description
Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by reducing gametocyte infectivity would be an additional benefit. To examine the effect of such therapy on transmission, Gambian children with Plasmodium falciparum malaria were treated with standard regimens of chloroquine or pyrimethamine-sulfadoxine alone or in combination with 1 or 3 doses of artesunate. The infectivity to mosquitoes of gametocytes in peripheral blood was determined 4 or 7 days after treatment. Infection of mosquitoes was observed in all treatment groups and was positively associated with gametocyte density. The probability of transmission was lowest in those who received pyrimethamine-sulfadoxine and 3 doses of artesunate, and it was 8-fold higher in the group that received pyrimethamine-sulfadoxine alone. Artesunate reduced posttreatment infectivity dramatically but did not abolish it completely. The study raises questions about any policy to use pyrimethamine-sulfadoxine alone as the first-line treatment for malaria. © 2001 by the Infectious Diseases Society of America.
Authors & Co-Authors
Targett, Geoffrey A.T.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Drakeley, Chris J.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Jawara, Musa
Gambia, Banjul
Medical Research Council Laboratories Gambia
Von-Seidlein, Lorenz
Gambia, Banjul
Medical Research Council Laboratories Gambia
Coleman, Rosalind L.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Deen, Jacqueline L.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Pinder, Margaret
Gambia, Banjul
Medical Research Council Laboratories Gambia
Doherty, Tom F.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sutherland, Colin J.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Walraven, Gijs E.L.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Milligan, Paul J.M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 205
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1086/319689
ISSN:
00221899
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health