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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical and virologic manifestations of primary Epstein-Barr virus (EBV) infection in Kenyan infants born to HIV-infected women
Journal of Infectious Diseases, Volume 207, No. 12, Year 2013
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Description
Background. Human immunodeficiency virus (HIV) infection is a risk factor for Epstein-Barr virus (EBV)-associated lymphomas. Characterizing primary infection may elucidate risk factors for malignancy.Methods. To describe clinical and virologic manifestations of primary EBV infection among infants born to HIV-infected women, specimens were utilized from a cohort study conducted in Nairobi, Kenya. HIV and EBV viral loads were measured serially in plasma. EBV serology was performed on EBV DNA-negative infants. Monthly clinical examinations were performed by pediatricians.Results. The probability of EBV infection by 1 year of age was. 78 (95% CI,. 67-.88) in HIV-infected and. 49 (95% CI,. 35-.65) in HIV-uninfected infants (P <. 0001). At 2 years, probability of EBV infection was. 96 (95% CI,. 89-.99) in HIV-infected infants. Peak EBV loads were higher in HIV-infected versus HIV-uninfected infants (median 2.6 vs 2.1 log10 copies/mL; P <. 0001). The majority of HIV-infected infants had detectable EBV DNA for >3 months (79%). Primary EBV infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and hospitalization in HIV-infected infants; conjunctivitis and rhinorrhea in HIV-uninfected infants.Conclusions. EBV infection occurs early in infants born to HIV-infected women. HIV infection was associated with more frequent and higher quantity EBV DNA detection. © 2013 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Slyker, Jennifer A.
United States, Seattle
University of Washington
Casper, Corey
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Tapia, Kenneth A.
United States, Seattle
University of Washington
Kenya, Nairobi
University of Nairobi
Richardson, Barbra Ann
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Kenya, Nairobi
University of Nairobi
Bunts, Lisa
United States, Seattle
Fred Hutchinson Cancer Research Center
Huang, Meeili Wu
United States, Seattle
University of Washington
Maleche-Obimbo, Elizabeth
Kenya, Nairobi
University of Nairobi
Nduati, Ruth W.
Kenya, Nairobi
University of Nairobi
John-Stewart, Grace C.
United States, Seattle
University of Washington
Statistics
Citations: 54
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/jit093
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Kenya
Participants Gender
Female