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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Malaria Morbidity in High and Seasonal Malaria Transmission Area of Burkina Faso
PLoS ONE, Volume 8, No. 1, Article e50036, Year 2013
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Description
Background: Malariometric parameters are often primary endpoints of efficacy trials of malaria vaccine candidates. This study aims to describe the epidemiology of malaria prior to the conduct of a series of drug and vaccine trials in a rural area of Burkina Faso. Methods: Malaria incidence was prospectively evaluated over one year follow-up among two cohorts of children aged 0-5 years living in the Saponé health district. The parents of 1089 children comprising a passive case detection cohort were encouraged to seek care from the local health clinic at any time their child felt sick. Among this cohort, 555 children were randomly selected for inclusion in an active surveillance sub-cohort evaluated for clinical malaria during twice weekly home visits. Malaria prevalence was evaluated by cross-sectional survey during the low and high transmission seasons. Results: Number of episodes per child ranged from 0 to 6 per year. Cumulative incidence was 67.4% in the passive and 86.2% in the active cohort and was highest among children 0-1 years. Clinical malaria prevalence was 9.8% in the low and 13.0% in the high season (p>0.05). Median days to first malaria episode ranged from 187 (95% CI 180-193) among children 0-1 years to 228 (95% CI 212, 242) among children 4-5 years. The alternative parasite thresholds for the malaria case definition that achieved optimal sensitivity and specificity (70-80%) were 3150 parasites/μl in the high and 1350 parasites/μl in the low season. Conclusion: Clinical malaria burden was highest among the youngest age group children, who may represent the most appropriate target population for malaria vaccine candidate development. The pyrogenic threshold of parasitaemia varied markedly by season, suggesting a value for alternative parasitaemia levels in the malaria case defintion. Regional epidemiology of malaria described, Sapone area field centers are positioned for future conduct of malaria vaccine trials. © 2013 Ouédraogo et al.
Authors & Co-Authors
Ouédraogo, Alphonse Risgou
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Tiono, Alfred Bewendtaoré
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Diarra, Amidou
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Sanon, Souleymane
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Yaro, Jean Baptiste
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Ouédraogo, Espérance B.
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Bougouma, Edith Christiane
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Soulama, Issiaka
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Gansané, Adama
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Ouédraogo, Alphonse P.
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Konaté, Amadou Tidiani
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Nèbiè, Issa O.
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Watson, Nora L.
United States, Rockville
The Emmes Corporation
Sanza, Megan
United States, Rockville
The Emmes Corporation
Dube, Tina J.T.
United States, Rockville
The Emmes Corporation
Sirima, Sodiomon Bienvenu
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Burkina Faso, Ouagadougou
Groupe de Recherche et D'action en Santé
Statistics
Citations: 45
Authors: 16
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0050036
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Burkina Faso