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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Vaccinia virus complement control protein significantly improves sensorimotor function recovery after severe head trauma
Brain Research, Volume 1153, No. 1, Year 2007
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Description
Vaccinia virus complement control protein (VCP) is an immunomodulator that inhibits both the classical and alternate pathways of the complement system, therefore preventing cell death and inflammation. VCP has previously been shown to be therapeutically effective in mild and moderate traumatic brain injury models. In this study the efficacy of VCP in a severe head injury model is investigated in Wistar rats. Training in a Morris Water Maze (MWM) commenced 2 days prior stereotaxic surgery. Rats were anesthetized before being subjected to a severe (2.7-3.0 atm) lateral fluid percussion injury (FPI) 3.0 mm lateral to the sagittal suture and 4.5 mm posterior to bregma. Ten microliters of VCP (1.7 μg/μl) was injected into the injury site immediately after FPI. Fourteen days post-FPI, rats were tested for spatial learning and memory using the Morris Water Maze, followed by a battery of sensorimotor tests. The latter tests showed statistically significant differences between saline-treated and VCP-treated rats in lateral left pulsion (p = 0.001) and tactile placing (p = 0.002) on the first 5 days of testing. In addition, significant differences in right lateral pulsion in the first 4 days (p = 0.007) of testing was evident. The results suggest that in a severe head injury model, VCP at this dosage favorably influences sensorimotor outcome. © 2007 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Pillay, Nirvana S.
South Africa, Cape Town
Faculty of Health Sciences
Kellaway, Lauriston A.
South Africa, Cape Town
Faculty of Health Sciences
Kotwal, Girish Jayant
South Africa, Cape Town
Faculty of Health Sciences
South Africa, Cape Town
Observatory
Statistics
Citations: 19
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.brainres.2007.03.056
ISSN:
00068993
Research Areas
Environmental
Health System And Policy
Violence And Injury