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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Hybrid selection for sequencing pathogen genomes from clinical samples
Genome Biology, Volume 12, No. 8, Article r73, Year 2011
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Description
We have adapted a solution hybrid selection protocol to enrich pathogen DNA in clinical samples dominated by human genetic material. Using mock mixtures of human and Plasmodium falciparum malaria parasite DNA as well as clinical samples from infected patients, we demonstrate an average of approximately 40-fold enrichment of parasite DNA after hybrid selection. This approach will enable efficient genome sequencing of pathogens from clinical samples, as well as sequencing of endosymbiotic organisms such as Wolbachia that live inside diverse metazoan phyla. © 2011 Melnikov et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3245613/bin/gb-2011-12-8-r73-S1.PDF
https://efashare.b-cdn.net/share/pmc/articles/PMC3245613/bin/gb-2011-12-8-r73-S2.XLS
https://efashare.b-cdn.net/share/pmc/articles/PMC3245613/bin/gb-2011-12-8-r73-S3.DOC
Authors & Co-Authors
Melnikov, Alexandre
United States, Cambridge
Broad Institute
Galinsky, Kevin J.
United States, Cambridge
Broad Institute
Rogov, Peter
United States, Cambridge
Broad Institute
Fennell, Timothy J.
United States, Cambridge
Broad Institute
Van-Tyne, Daria
United States, Boston
Harvard T.h. Chan School of Public Health
Russ, Carsten
United States, Cambridge
Broad Institute
Daniels, Rachel F.
United States, Cambridge
Broad Institute
Barnes, Kayla G.
United States, Boston
Harvard T.h. Chan School of Public Health
Bochicchio, James
United States, Cambridge
Broad Institute
Ndiaye, Daouda F.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sène, Papa Diogoye
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Wirth, Dyann F.
United States, Boston
Harvard T.h. Chan School of Public Health
Nusbaum, Chad
United States, Cambridge
Broad Institute
Volkman, Sarah K.
United States, Boston
Harvard T.h. Chan School of Public Health
Birren, Bruce W.
United States, Cambridge
Broad Institute
Gnirke, Andreas
United States, Cambridge
Broad Institute
Neafsey, Daniel E.
United States, Cambridge
Broad Institute
Statistics
Citations: 105
Authors: 17
Affiliations: 3
Identifiers
Doi:
10.1186/gb-2011-12-8-r73
ISSN:
14747596
e-ISSN:
1474760X
Research Areas
Genetics And Genomics
Infectious Diseases