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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical efficacy of combination of rifampin and streptomycin for treatment of Mycobacterium ulcerans disease
Antimicrobial Agents and Chemotherapy, Volume 54, No. 9, Year 2010
Notification
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Description
We have evaluated the clinical efficacy of the combination of oral rifampin at 10 mg/kg of body weight and intramuscular streptomycin at 15 mg/kg for 8 weeks (RS8), as recommended by the WHO, in 160 PCR-confirmed cases of Mycobacterium ulcerans disease. In 152 patients (95%) with all forms of disease from early nodules to large ulcers, with or without edema, the lesions healed without recourse to surgery. Eight patients whose ulcers were healing poorly had skin grafting after completion of antibiotics. There were no recurrences among 158 patients reviewed at the 1-year follow-up. The times to complete healing ranged from 2 to 48 weeks, according to the type and size of the lesion, but the average rate of healing (rate of reduction in ulcer diameter) varied widely. Thirteen subjects had positive cultures for M. ulcerans during or after treatment, but all the lesions healed without further antibiotic treatment. Adverse events were rare. These results confirm the efficacy of RS8 delivered in a community setting. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Sarfo, Fred Stephen
Unknown Affiliation
Phillips, Richard Odame
Unknown Affiliation
Asiedu, Kingsley Bampoe
Unknown Affiliation
Ampadu, Edwin O.
Unknown Affiliation
Bobi, Nana
Unknown Affiliation
Adentwe, E.
Unknown Affiliation
Lartey, A.
Unknown Affiliation
Tetteh, I.
Unknown Affiliation
Wansbrough-Jones, Mark H.
Unknown Affiliation
Statistics
Citations: 117
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1128/AAC.00299-10
ISSN:
00664804
e-ISSN:
10986596
Research Areas
Health System And Policy
Study Design
Cohort Study