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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Blocking IL-1α but not IL-1β increases susceptibility to chronic Mycobacterium tuberculosis infection in mice
Vaccine, Volume 29, No. 6, Year 2011
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Description
IL-1α and IL-1β are potent inflammatory cytokines and important mediators of immune responses to intracellular pathogens such as Mycobacterium tuberculosis (Mtb). Here, we investigated the role of IL-1α and IL-1β during chronic Mtb infection and spontaneous reactivation in mice. For long-term neutralization of IL-1α, IL-1β or both, mice were immunized with virus-like particles (VLPs) displaying either of the cytokines, inducing strong and long-lasting neutralizing IgG responses. Blocking of IL-1α but not of IL-1β resulted in increased susceptibility to chronic infection with Mtb. Neutralizing either IL-1α or IL-1β alone did not lead to increased reactivation of latent tuberculosis. The generation of antibodies neutralizing both IL-1α and IL-1β simultaneously, did not influence weight gain during Mtb reactivation and the slight increase in pulmonary bacillary counts were not significant when compared to control-immunized group. Thus, the results suggest that IL-1α is the major mediator of the IL-1RI-dependent and protective innate immune responses to Mtb in mice. © 2010.
Authors & Co-Authors
Guler, Reto
South Africa, Cape Town
University of Cape Town
Parihar, Suraj P.
South Africa, Cape Town
University of Cape Town
Spohn, Gunther
Switzerland, Schlieren
Cytos Biotechnology ag
Johansen, Pål
Switzerland, Zurich
Universitätsspital Zürich, Dermatologische Klinik
Brombacher, Frank
South Africa, Cape Town
University of Cape Town
Bachmann, Martin F.
Switzerland, Schlieren
Cytos Biotechnology ag
Statistics
Citations: 59
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.vaccine.2010.10.045
ISSN:
0264410X