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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Seroprevalence of HTLV-1/2 infection among native and immigrant pregnant women in Spain
AIDS Research and Human Retroviruses, Volume 25, No. 6, Year 2009
Notification
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Description
HTLV-1/2 antenatal screening is not mandatory in European countries. The rapid increase in immigrants coming from areas endemic for HTLV-1 infection has compelled a review of this policy in Spain. From February 2006 to December 2007, a cross-sectional study was carried out in all pregnant women attended at 10 different Spanish hospitals. An enzyme immunoassay (EIA) was used to test serum HTLV-1/2 antibodies; reactive samples were further confirmed by Western blot and/or polymerase chain reaction. A total of 20,518 pregnant women were examined, of whom 18,266 (89%) were native Spaniards. Overall, 946 (4.6%) of the immigrants came from HTLV-1 endemic areas (mainly Central and South America and sub-Saharan Africa). Four samples were EIA seroreactive for HTLV-1/2, two of them in women infected with HTLV-1 coming from endemic areas. The other two women were infected with HTLV-2; one was an immigrant from Bolivia and another was a native Spaniard who admitted prior injection drug use and was HIV-1 positive. The overall HTLV-1/2 seroprevalence was 0.19 per 1000 (95% CI: 0.05-0.49/1000). For HTLV-1, the seroprevalence was 2.11 per 1000 (95% CI: 0.26-7.62/1000) in pregnant women from endemic areas. The seroprevalence of HTLV-1/2 infection is below 0.02% among pregnant women in Spain, and therefore universal screening for HTLV-1/2 infection in antenatal clinics is not warranted. However, HTLV-1/2 screening could be considered in pregnant women coming from endemic areas, in whom the rate of infection is nearly 1000-fold higher than in native Spaniards and are the only group infected with the more pathogenic HTLV-1. © 2009, Mary Ann Liebert, Inc.
Authors & Co-Authors
Aguilera, Antonio
Unknown Affiliation
Toro, Carlos
Spain, Madrid
Hospital Universitario la Paz
Eiros-Bouza, José María
Spain, Valladolid
Hospital Clínico Universitario de Valladolid
de Lejarazu, Raúl Ortíz
Spain, Valladolid
Hospital Clínico Universitario de Valladolid
Iglesias, M. A.R.
Spain, Cadiz
Hospital Universitario de Puerto Real
Ramos-Rincón, José Manuel
Unknown Affiliation
Calderón, Enrique J.
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
García, Juan González
Unknown Affiliation
Rodríguez, Carmen
Unknown Affiliation
Soriano, Vicente Vicente
Spain, Madrid
Hospital Universitario la Paz
Statistics
Citations: 27
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.1089/aid.2008.0268
ISSN:
08892229
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Female